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Biomarkers for prostate cancer: present challenges and future opportunities

Prostate cancer (PCa) has variable biological potential with multiple treatment options. A more personalized approach, therefore, is needed to better define men at higher risk of developing PCa, discriminate indolent from aggressive disease and improve risk stratification after treatment by predicti...

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Detalles Bibliográficos
Autores principales: Sharma, Pranav, Zargar-Shoshtari, Kamran, Pow-Sang, Julio M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137959/
https://www.ncbi.nlm.nih.gov/pubmed/28031932
http://dx.doi.org/10.4155/fso.15.72
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author Sharma, Pranav
Zargar-Shoshtari, Kamran
Pow-Sang, Julio M
author_facet Sharma, Pranav
Zargar-Shoshtari, Kamran
Pow-Sang, Julio M
author_sort Sharma, Pranav
collection PubMed
description Prostate cancer (PCa) has variable biological potential with multiple treatment options. A more personalized approach, therefore, is needed to better define men at higher risk of developing PCa, discriminate indolent from aggressive disease and improve risk stratification after treatment by predicting the likelihood of progression. This may improve clinical decision-making regarding management, improve selection for active surveillance protocols and minimize morbidity from treatment. Discovery of new biomarkers associated with prostate carcinogenesis present an opportunity to provide patients with novel genetic signatures to better understand their risk of developing PCa and help forecast their clinical course. In this review, we examine the current literature evaluating biomarkers in PCa. We also address current limitations and present several ideas for future studies.
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spelling pubmed-51379592016-12-28 Biomarkers for prostate cancer: present challenges and future opportunities Sharma, Pranav Zargar-Shoshtari, Kamran Pow-Sang, Julio M Future Sci OA Review Prostate cancer (PCa) has variable biological potential with multiple treatment options. A more personalized approach, therefore, is needed to better define men at higher risk of developing PCa, discriminate indolent from aggressive disease and improve risk stratification after treatment by predicting the likelihood of progression. This may improve clinical decision-making regarding management, improve selection for active surveillance protocols and minimize morbidity from treatment. Discovery of new biomarkers associated with prostate carcinogenesis present an opportunity to provide patients with novel genetic signatures to better understand their risk of developing PCa and help forecast their clinical course. In this review, we examine the current literature evaluating biomarkers in PCa. We also address current limitations and present several ideas for future studies. Future Science Ltd 2015-12-17 /pmc/articles/PMC5137959/ /pubmed/28031932 http://dx.doi.org/10.4155/fso.15.72 Text en © JM Pow-Sang This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Sharma, Pranav
Zargar-Shoshtari, Kamran
Pow-Sang, Julio M
Biomarkers for prostate cancer: present challenges and future opportunities
title Biomarkers for prostate cancer: present challenges and future opportunities
title_full Biomarkers for prostate cancer: present challenges and future opportunities
title_fullStr Biomarkers for prostate cancer: present challenges and future opportunities
title_full_unstemmed Biomarkers for prostate cancer: present challenges and future opportunities
title_short Biomarkers for prostate cancer: present challenges and future opportunities
title_sort biomarkers for prostate cancer: present challenges and future opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137959/
https://www.ncbi.nlm.nih.gov/pubmed/28031932
http://dx.doi.org/10.4155/fso.15.72
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