Cargando…

Noninvasive metabolic profiling for painless diagnosis of human diseases and disorders

Metabolic profiling provides a powerful diagnostic tool complementary to genomics and proteomics. The pain, discomfort and probable iatrogenic injury associated with invasive or minimally invasive diagnostic methods, render them unsuitable in terms of patient compliance and participation. Metabolic...

Descripción completa

Detalles Bibliográficos
Autor principal: Mal, Mainak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137983/
https://www.ncbi.nlm.nih.gov/pubmed/28031956
http://dx.doi.org/10.4155/fsoa-2015-0014
_version_ 1782471994096222208
author Mal, Mainak
author_facet Mal, Mainak
author_sort Mal, Mainak
collection PubMed
description Metabolic profiling provides a powerful diagnostic tool complementary to genomics and proteomics. The pain, discomfort and probable iatrogenic injury associated with invasive or minimally invasive diagnostic methods, render them unsuitable in terms of patient compliance and participation. Metabolic profiling of biomatrices like urine, breath, saliva, sweat and feces, which can be collected in a painless manner, could be used for noninvasive diagnosis. This review article covers the noninvasive metabolic profiling studies that have exhibited diagnostic potential for diseases and disorders. Their potential applications are evident in different forms of cancer, metabolic disorders, infectious diseases, neurodegenerative disorders, rheumatic diseases and pulmonary diseases. Large scale clinical validation of such diagnostic methods is necessary in future.
format Online
Article
Text
id pubmed-5137983
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Future Science Ltd
record_format MEDLINE/PubMed
spelling pubmed-51379832016-12-28 Noninvasive metabolic profiling for painless diagnosis of human diseases and disorders Mal, Mainak Future Sci OA Review Metabolic profiling provides a powerful diagnostic tool complementary to genomics and proteomics. The pain, discomfort and probable iatrogenic injury associated with invasive or minimally invasive diagnostic methods, render them unsuitable in terms of patient compliance and participation. Metabolic profiling of biomatrices like urine, breath, saliva, sweat and feces, which can be collected in a painless manner, could be used for noninvasive diagnosis. This review article covers the noninvasive metabolic profiling studies that have exhibited diagnostic potential for diseases and disorders. Their potential applications are evident in different forms of cancer, metabolic disorders, infectious diseases, neurodegenerative disorders, rheumatic diseases and pulmonary diseases. Large scale clinical validation of such diagnostic methods is necessary in future. Future Science Ltd 2016-06-10 /pmc/articles/PMC5137983/ /pubmed/28031956 http://dx.doi.org/10.4155/fsoa-2015-0014 Text en © Mainak Mal This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Mal, Mainak
Noninvasive metabolic profiling for painless diagnosis of human diseases and disorders
title Noninvasive metabolic profiling for painless diagnosis of human diseases and disorders
title_full Noninvasive metabolic profiling for painless diagnosis of human diseases and disorders
title_fullStr Noninvasive metabolic profiling for painless diagnosis of human diseases and disorders
title_full_unstemmed Noninvasive metabolic profiling for painless diagnosis of human diseases and disorders
title_short Noninvasive metabolic profiling for painless diagnosis of human diseases and disorders
title_sort noninvasive metabolic profiling for painless diagnosis of human diseases and disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137983/
https://www.ncbi.nlm.nih.gov/pubmed/28031956
http://dx.doi.org/10.4155/fsoa-2015-0014
work_keys_str_mv AT malmainak noninvasivemetabolicprofilingforpainlessdiagnosisofhumandiseasesanddisorders