Role of STAT3 pathway in genitourinary tumors

The STAT3 is often dysregulated in genitourinary tumors. In prostate cancer, STAT3 activation correlates with Gleason score and pathological stage and modulates cancer stem cells and epithelial–mesenchymal transition. In addition, STAT3 promotes the progression from carcinoma in situ to invasive bla...

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Autores principales: Santoni, Matteo, Conti, Alessandro, Piva, Francesco, Massari, Francesco, Ciccarese, Chiara, Burattini, Luciano, Cheng, Liang, Lopez-Beltran, Antonio, Scarpelli, Marina, Santini, Daniele, Tortora, Giampaolo, Cascinu, Stefano, Montironi, Rodolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137995/
https://www.ncbi.nlm.nih.gov/pubmed/28031890
http://dx.doi.org/10.4155/fso.15.13
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author Santoni, Matteo
Conti, Alessandro
Piva, Francesco
Massari, Francesco
Ciccarese, Chiara
Burattini, Luciano
Cheng, Liang
Lopez-Beltran, Antonio
Scarpelli, Marina
Santini, Daniele
Tortora, Giampaolo
Cascinu, Stefano
Montironi, Rodolfo
author_facet Santoni, Matteo
Conti, Alessandro
Piva, Francesco
Massari, Francesco
Ciccarese, Chiara
Burattini, Luciano
Cheng, Liang
Lopez-Beltran, Antonio
Scarpelli, Marina
Santini, Daniele
Tortora, Giampaolo
Cascinu, Stefano
Montironi, Rodolfo
author_sort Santoni, Matteo
collection PubMed
description The STAT3 is often dysregulated in genitourinary tumors. In prostate cancer, STAT3 activation correlates with Gleason score and pathological stage and modulates cancer stem cells and epithelial–mesenchymal transition. In addition, STAT3 promotes the progression from carcinoma in situ to invasive bladder cancer and modulates renal cell carcinoma angiogenesis by increasing the expression of HIF1α and VEGF. STAT3 is also involved in the response to tyrosine kinase inhibitors sunitinib and axitinib, in patients with metastatic renal cell carcinoma, and to second-generation androgen receptor inhibitor enzalutamide in patients with advanced prostate cancer. In this review, we describe the role of STAT3 in genitourinary tumors, thus describing its potential for future therapeutic strategies.
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spelling pubmed-51379952016-12-28 Role of STAT3 pathway in genitourinary tumors Santoni, Matteo Conti, Alessandro Piva, Francesco Massari, Francesco Ciccarese, Chiara Burattini, Luciano Cheng, Liang Lopez-Beltran, Antonio Scarpelli, Marina Santini, Daniele Tortora, Giampaolo Cascinu, Stefano Montironi, Rodolfo Future Sci OA Review The STAT3 is often dysregulated in genitourinary tumors. In prostate cancer, STAT3 activation correlates with Gleason score and pathological stage and modulates cancer stem cells and epithelial–mesenchymal transition. In addition, STAT3 promotes the progression from carcinoma in situ to invasive bladder cancer and modulates renal cell carcinoma angiogenesis by increasing the expression of HIF1α and VEGF. STAT3 is also involved in the response to tyrosine kinase inhibitors sunitinib and axitinib, in patients with metastatic renal cell carcinoma, and to second-generation androgen receptor inhibitor enzalutamide in patients with advanced prostate cancer. In this review, we describe the role of STAT3 in genitourinary tumors, thus describing its potential for future therapeutic strategies. Future Science Ltd 2015-11-01 /pmc/articles/PMC5137995/ /pubmed/28031890 http://dx.doi.org/10.4155/fso.15.13 Text en © M Santoni et al. This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Santoni, Matteo
Conti, Alessandro
Piva, Francesco
Massari, Francesco
Ciccarese, Chiara
Burattini, Luciano
Cheng, Liang
Lopez-Beltran, Antonio
Scarpelli, Marina
Santini, Daniele
Tortora, Giampaolo
Cascinu, Stefano
Montironi, Rodolfo
Role of STAT3 pathway in genitourinary tumors
title Role of STAT3 pathway in genitourinary tumors
title_full Role of STAT3 pathway in genitourinary tumors
title_fullStr Role of STAT3 pathway in genitourinary tumors
title_full_unstemmed Role of STAT3 pathway in genitourinary tumors
title_short Role of STAT3 pathway in genitourinary tumors
title_sort role of stat3 pathway in genitourinary tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137995/
https://www.ncbi.nlm.nih.gov/pubmed/28031890
http://dx.doi.org/10.4155/fso.15.13
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