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The melding of nanomedicine in thrombosis imaging and treatment: a review
Thromboembolic diseases constitute a plague in our century, wherein an imbalance of hemostasis leads to thrombus formation and vessels constriction reducing blood flow. Hence, the recent rise of nanomedicine gives birth to advanced diagnostic modalities and therapeutic agents for the early diagnosis...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138016/ https://www.ncbi.nlm.nih.gov/pubmed/28031960 http://dx.doi.org/10.4155/fso.16.3 |
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author | Karagkiozaki, Varvara Pappa, Foteini Arvaniti, Despoina Moumkas, Anestis Konstantinou, Dimitrios Logothetidis, Stergios |
author_facet | Karagkiozaki, Varvara Pappa, Foteini Arvaniti, Despoina Moumkas, Anestis Konstantinou, Dimitrios Logothetidis, Stergios |
author_sort | Karagkiozaki, Varvara |
collection | PubMed |
description | Thromboembolic diseases constitute a plague in our century, wherein an imbalance of hemostasis leads to thrombus formation and vessels constriction reducing blood flow. Hence, the recent rise of nanomedicine gives birth to advanced diagnostic modalities and therapeutic agents for the early diagnosis and treatment of such diseases. Multimodal nanoagents for the detection of intravascular thrombi and nanovehicles for thrombus-targeted fibrinolytic therapy are few paradigms of nanomedicine approaches to overcome current diagnostic treatment roadblocks and persistent clinical needs. This review highlights the nanomedicine strategies to improve the imaging and therapy of acute thrombi by nanoparticles and nanotheranostics, the detailed imaging of thrombogenic proteins and platelets via atomic force microscopy with the knowledge basis of thrombosis pathophysiology and nanotoxicity. |
format | Online Article Text |
id | pubmed-5138016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51380162016-12-28 The melding of nanomedicine in thrombosis imaging and treatment: a review Karagkiozaki, Varvara Pappa, Foteini Arvaniti, Despoina Moumkas, Anestis Konstantinou, Dimitrios Logothetidis, Stergios Future Sci OA Review Thromboembolic diseases constitute a plague in our century, wherein an imbalance of hemostasis leads to thrombus formation and vessels constriction reducing blood flow. Hence, the recent rise of nanomedicine gives birth to advanced diagnostic modalities and therapeutic agents for the early diagnosis and treatment of such diseases. Multimodal nanoagents for the detection of intravascular thrombi and nanovehicles for thrombus-targeted fibrinolytic therapy are few paradigms of nanomedicine approaches to overcome current diagnostic treatment roadblocks and persistent clinical needs. This review highlights the nanomedicine strategies to improve the imaging and therapy of acute thrombi by nanoparticles and nanotheranostics, the detailed imaging of thrombogenic proteins and platelets via atomic force microscopy with the knowledge basis of thrombosis pathophysiology and nanotoxicity. Future Science Ltd 2016-03-23 /pmc/articles/PMC5138016/ /pubmed/28031960 http://dx.doi.org/10.4155/fso.16.3 Text en © V Karagkiozaki & S Logothetidis This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Review Karagkiozaki, Varvara Pappa, Foteini Arvaniti, Despoina Moumkas, Anestis Konstantinou, Dimitrios Logothetidis, Stergios The melding of nanomedicine in thrombosis imaging and treatment: a review |
title | The melding of nanomedicine in thrombosis imaging and treatment: a review |
title_full | The melding of nanomedicine in thrombosis imaging and treatment: a review |
title_fullStr | The melding of nanomedicine in thrombosis imaging and treatment: a review |
title_full_unstemmed | The melding of nanomedicine in thrombosis imaging and treatment: a review |
title_short | The melding of nanomedicine in thrombosis imaging and treatment: a review |
title_sort | melding of nanomedicine in thrombosis imaging and treatment: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138016/ https://www.ncbi.nlm.nih.gov/pubmed/28031960 http://dx.doi.org/10.4155/fso.16.3 |
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