Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

Adult stem cells may acquire mutations that modify cellular behavior, leading to functional declines in homeostasis or providing a competitive advantage resulting in premalignancy. However, the frequency, phenotypic impact, and mechanisms underlying spontaneous mutagenesis during aging are unclear....

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Detalles Bibliográficos
Autores principales: Siudeja, Katarzyna, Nassari, Sonya, Gervais, Louis, Skorski, Patricia, Lameiras, Sonia, Stolfa, Donato, Zande, Maria, Bernard, Virginie, Frio, Thomas Rio, Bardin, Allison J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138153/
https://www.ncbi.nlm.nih.gov/pubmed/26607382
http://dx.doi.org/10.1016/j.stem.2015.09.016

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