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Treating hepatocellular carcinoma with (90)Y-bearing microspheres: a review

Hepatocellular carcinoma (HCC) is a disease usually diagnosed in its advanced-stage, and is frequently not amenable to curative surgical treatment. Also, HCC is resistant to chemotherapy and less vulnerable to radiation therapy compared to normal hepatic parenchyma. Both of these facts render the ef...

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Autores principales: Hsieh, Te-Chun, Wu, Yu-Chin, Sun, Shung-Shung, Yen, Kuo-Yang, Kao, Chia-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: China Medical University 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138159/
https://www.ncbi.nlm.nih.gov/pubmed/27848114
http://dx.doi.org/10.7603/s40681-016-0019-z
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author Hsieh, Te-Chun
Wu, Yu-Chin
Sun, Shung-Shung
Yen, Kuo-Yang
Kao, Chia-Hung
author_facet Hsieh, Te-Chun
Wu, Yu-Chin
Sun, Shung-Shung
Yen, Kuo-Yang
Kao, Chia-Hung
author_sort Hsieh, Te-Chun
collection PubMed
description Hepatocellular carcinoma (HCC) is a disease usually diagnosed in its advanced-stage, and is frequently not amenable to curative surgical treatment. Also, HCC is resistant to chemotherapy and less vulnerable to radiation therapy compared to normal hepatic parenchyma. Both of these facts render the efficacy of adjuvant and palliative treatments problematic. Selective internal radiation therapy (SIRT) with (90)Y-bearing microspheres is characterized by preferentially delivering substantially high doses of radiation to a liver tumor dose simultaneously limiting the damage to its non-tumorous cells, providing an opportunity for effective local tumor control and even tumor regression therapy. The current article reviews the specific characters, dosimetry, possible applications, and special considerations toward the pre-existing radiation therapy of (90)Y microsphere SIRT in treating HCC.
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spelling pubmed-51381592016-12-30 Treating hepatocellular carcinoma with (90)Y-bearing microspheres: a review Hsieh, Te-Chun Wu, Yu-Chin Sun, Shung-Shung Yen, Kuo-Yang Kao, Chia-Hung Biomedicine (Taipei) Review Article Hepatocellular carcinoma (HCC) is a disease usually diagnosed in its advanced-stage, and is frequently not amenable to curative surgical treatment. Also, HCC is resistant to chemotherapy and less vulnerable to radiation therapy compared to normal hepatic parenchyma. Both of these facts render the efficacy of adjuvant and palliative treatments problematic. Selective internal radiation therapy (SIRT) with (90)Y-bearing microspheres is characterized by preferentially delivering substantially high doses of radiation to a liver tumor dose simultaneously limiting the damage to its non-tumorous cells, providing an opportunity for effective local tumor control and even tumor regression therapy. The current article reviews the specific characters, dosimetry, possible applications, and special considerations toward the pre-existing radiation therapy of (90)Y microsphere SIRT in treating HCC. China Medical University 2016-12-06 /pmc/articles/PMC5138159/ /pubmed/27848114 http://dx.doi.org/10.7603/s40681-016-0019-z Text en © China Medical University 2016 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited.
spellingShingle Review Article
Hsieh, Te-Chun
Wu, Yu-Chin
Sun, Shung-Shung
Yen, Kuo-Yang
Kao, Chia-Hung
Treating hepatocellular carcinoma with (90)Y-bearing microspheres: a review
title Treating hepatocellular carcinoma with (90)Y-bearing microspheres: a review
title_full Treating hepatocellular carcinoma with (90)Y-bearing microspheres: a review
title_fullStr Treating hepatocellular carcinoma with (90)Y-bearing microspheres: a review
title_full_unstemmed Treating hepatocellular carcinoma with (90)Y-bearing microspheres: a review
title_short Treating hepatocellular carcinoma with (90)Y-bearing microspheres: a review
title_sort treating hepatocellular carcinoma with (90)y-bearing microspheres: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138159/
https://www.ncbi.nlm.nih.gov/pubmed/27848114
http://dx.doi.org/10.7603/s40681-016-0019-z
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