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The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches
Gap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites. They consist of two connexons, with (one) connexon supplied by each cell. A connexon is a hexamer of connexins and curren...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138227/ https://www.ncbi.nlm.nih.gov/pubmed/27999549 http://dx.doi.org/10.3389/fphys.2016.00596 |
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author | Wong, Pui Tan, Teresa Chan, Catherine Laxton, Victoria Chan, Yin Wah Fiona Liu, Tong Wong, Wing Tak Tse, Gary |
author_facet | Wong, Pui Tan, Teresa Chan, Catherine Laxton, Victoria Chan, Yin Wah Fiona Liu, Tong Wong, Wing Tak Tse, Gary |
author_sort | Wong, Pui |
collection | PubMed |
description | Gap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites. They consist of two connexons, with (one) connexon supplied by each cell. A connexon is a hexamer of connexins and currently more than 20 connexin isoforms have been described in the literature thus far. Connexins have a short half-life, and therefore gap junction remodeling constantly occurs with a high turnover rate. Post-translational modification, such as phosphorylation, can modify their channel activities. In this article, the roles of connexins in wound healing and repair are reviewed. Novel strategies for modulating the function or expression of connexins, such as the use of antisense technology, synthetic mimetic peptides and bioactive materials for the treatment of skin wounds, diabetic and pressure ulcers as well as cornea wounds, are considered. |
format | Online Article Text |
id | pubmed-5138227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51382272016-12-20 The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches Wong, Pui Tan, Teresa Chan, Catherine Laxton, Victoria Chan, Yin Wah Fiona Liu, Tong Wong, Wing Tak Tse, Gary Front Physiol Physiology Gap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites. They consist of two connexons, with (one) connexon supplied by each cell. A connexon is a hexamer of connexins and currently more than 20 connexin isoforms have been described in the literature thus far. Connexins have a short half-life, and therefore gap junction remodeling constantly occurs with a high turnover rate. Post-translational modification, such as phosphorylation, can modify their channel activities. In this article, the roles of connexins in wound healing and repair are reviewed. Novel strategies for modulating the function or expression of connexins, such as the use of antisense technology, synthetic mimetic peptides and bioactive materials for the treatment of skin wounds, diabetic and pressure ulcers as well as cornea wounds, are considered. Frontiers Media S.A. 2016-12-06 /pmc/articles/PMC5138227/ /pubmed/27999549 http://dx.doi.org/10.3389/fphys.2016.00596 Text en Copyright © 2016 Wong, Tan, Chan, Laxton, Chan, Liu, Wong and Tse. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Wong, Pui Tan, Teresa Chan, Catherine Laxton, Victoria Chan, Yin Wah Fiona Liu, Tong Wong, Wing Tak Tse, Gary The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches |
title | The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches |
title_full | The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches |
title_fullStr | The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches |
title_full_unstemmed | The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches |
title_short | The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches |
title_sort | role of connexins in wound healing and repair: novel therapeutic approaches |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138227/ https://www.ncbi.nlm.nih.gov/pubmed/27999549 http://dx.doi.org/10.3389/fphys.2016.00596 |
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