Cargando…

“Freeze, Don’t Move”: How to Arrest a Suspect in Heart Failure – A Review on Available GRK2 Inhibitors

Cardiovascular disease and heart failure (HF) still collect the largest toll of death in western societies and all over the world. A growing number of molecular mechanisms represent possible targets for new therapeutic strategies, which can counteract the metabolic and structural changes observed in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sorriento, Daniela, Ciccarelli, Michele, Cipolletta, Ersilia, Trimarco, Bruno, Iaccarino, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138235/ https://www.ncbi.nlm.nih.gov/pubmed/27999776 http://dx.doi.org/10.3389/fcvm.2016.00048

Ejemplares similares

Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization.
por: Sorriento, Daniela, et al.
Publicado: (2014)

Antidiabetic and Cardioprotective Effects of Pharmacological Inhibition of GRK2 in db/db Mice
por: Cipolletta, Ersilia, et al.
Publicado: (2019)

Dual role of GRK5 in cancer development and progression
por: Gambardella, J, et al.
Publicado: (2016)

The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors
por: Sorriento, Daniela, et al.
Publicado: (2018)

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure
por: Ciccarelli, Michele, et al.
Publicado: (2020)

GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion
por: Franco, Antonietta, et al.
Publicado: (2018)

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions
por: Sorriento, Daniela, et al.
Publicado: (2021)

A Polymorphism within the Promoter of the Dopamine Receptor D1 (DRD1 -48A/G) Associates with Impaired Kidney Function in White Hypertensive Patients
por: Cipolletta, Ersilia, et al.
Publicado: (2012)

Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis
por: Gambardella, Jessica, et al.
Publicado: (2020)

Commentary: Studies in Zebrafish Demonstrate That CNNM2 and NT5C2 Are Most Likely the Causal Genes at the Blood Pressure-Associated Locus on Human Chromosome 10q24.32
por: Sorriento, Daniela, et al.
Publicado: (2020)

Plasmodium malariae in the Colombian Amazon region: you don’t diagnose what you don’t suspect
por: Niño, Carlos Hernando, et al.
Publicado: (2016)

Adrenergic Mechanism in the Control of Endothelial Function
por: Sorriento, Daniela, et al.
Publicado: (2011)

“They Don't Know, Don't Show, or Don't Care”: Autism's White Privilege Problem
por: Giwa Onaiwu, Morénike
Publicado: (2020)

Don’t
Publicado: (1879)

CaMK4 Gene Deletion Induces Hypertension
por: Santulli, Gaetano, et al.
Publicado: (2012)

Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy
por: Cipolletta, Ersilia, et al.
Publicado: (2015)

Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs
por: Gambardella, Jessica, et al.
Publicado: (2017)

IN A TIME OF VIRAL SPREAD, DON'T FORGET THE USUAL SUSPECTS
por: CHAN, VERNON, et al.
Publicado: (2021)

Alpha2-Antiplasmin: The Devil You Don't Know in Cerebrovascular and Cardiovascular Disease
por: Singh, Satish, et al.
Publicado: (2020)

Don't Roll Your Manuscripts; and Other Don'ts
Publicado: (1879)

Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications
por: Gambardella, Jessica, et al.
Publicado: (2018)

Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system
por: Santulli, Gaetano, et al.
Publicado: (2013)

The Antioxidant Therapy: New Insights in the Treatment of Hypertension
por: Sorriento, Daniela, et al.
Publicado: (2018)

Don't overreact
por: Williams, Ruth
Publicado: (2006)

Don't miss
Publicado: (2020)

Don't miss
Publicado: (2020)

Don't miss
Publicado: (2020)

Don’t Overshoot
Publicado: (1874)

Don’t seek, don’t find: The diagnostic challenge of Wernicke’s encephalopathy
por: Kohnke, Sara, et al.
Publicado: (2020)

Sustainable policy: Don't get infected and don't infect others
por: Takefuji, Yoshiyasu
Publicado: (2022)

The first two rules of leadership: don't be stupid, don't be a jerk
por: Cottrell, David M
Publicado: (2016)

Do, don’t and don’t know: guidelines for medical education with a difference
por: McKinley, Robert K., et al.
Publicado: (2015)

Guidelines: the do’s, don’ts and don’t knows of feedback for clinical education
por: Lefroy, Janet, et al.
Publicado: (2015)

The do’s, don’t and don’t knows of supporting transition to more independent practice
por: Yardley, Sarah, et al.
Publicado: (2018)

Guidelines: The dos, don’ts and don’t knows of remediation in medical education
por: Chou, Calvin L., et al.
Publicado: (2019)

Don’t abandon RCTs in IVF. We don’t even understand them
por: Wilkinson, J, et al.
Publicado: (2019)

Commentary: When we don't know what we don't know
por: Paone, Gaetano
Publicado: (2020)

Rays Sting: The Acute Cellular Effects of Ionizing Radiation Exposure
por: Franco, A, et al.
Publicado: (2016)

Adrenergic receptors and metabolism: role in development of cardiovascular disease
por: Ciccarelli, Michele, et al.
Publicado: (2013)

Right Ventricular Cardiomyopathy Meeting the Arrhythmogenic Right Ventricular Dysplasia Revised Criteria? Don't Forget Sarcoidosis!
por: Vasaturo, Sabina, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hl6bg5q2a7ejr8ecgpt19b5rvb