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Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits
Ultrasound microbubble combined optic protection drugs have obvious protective effect on optic nerve damage. This way of targeting drug delivery is becoming more simple, not through the whole body metabolism, avoiding drug via blood circulation when facing the decomposition and the environment in th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138486/ https://www.ncbi.nlm.nih.gov/pubmed/27994883 http://dx.doi.org/10.1155/2016/4235923 |
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author | Shen, Xiaoli Huang, Lina Ma, Dahui Zhao, Jun Xie, Yi Li, Qiang Zeng, Aineng Zeng, Kun Tian, Ruyin Wang, Tianfu Chen, Siping |
author_facet | Shen, Xiaoli Huang, Lina Ma, Dahui Zhao, Jun Xie, Yi Li, Qiang Zeng, Aineng Zeng, Kun Tian, Ruyin Wang, Tianfu Chen, Siping |
author_sort | Shen, Xiaoli |
collection | PubMed |
description | Ultrasound microbubble combined optic protection drugs have obvious protective effect on optic nerve damage. This way of targeting drug delivery is becoming more simple, not through the whole body metabolism, avoiding drug via blood circulation when facing the decomposition and the environment in the interference and destruction process of drugs, to maximize the guarantee to reach target organs of drug concentration and to reache the maximum therapeutic effect. The technique of ultrasound microbubbles is safe, controllable, nonimmunogenic, and repeatable. It provides us with a novel idea in the administration of neuroprotective drugs. |
format | Online Article Text |
id | pubmed-5138486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51384862016-12-19 Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits Shen, Xiaoli Huang, Lina Ma, Dahui Zhao, Jun Xie, Yi Li, Qiang Zeng, Aineng Zeng, Kun Tian, Ruyin Wang, Tianfu Chen, Siping J Ophthalmol Research Article Ultrasound microbubble combined optic protection drugs have obvious protective effect on optic nerve damage. This way of targeting drug delivery is becoming more simple, not through the whole body metabolism, avoiding drug via blood circulation when facing the decomposition and the environment in the interference and destruction process of drugs, to maximize the guarantee to reach target organs of drug concentration and to reache the maximum therapeutic effect. The technique of ultrasound microbubbles is safe, controllable, nonimmunogenic, and repeatable. It provides us with a novel idea in the administration of neuroprotective drugs. Hindawi Publishing Corporation 2016 2016-11-22 /pmc/articles/PMC5138486/ /pubmed/27994883 http://dx.doi.org/10.1155/2016/4235923 Text en Copyright © 2016 Xiaoli Shen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shen, Xiaoli Huang, Lina Ma, Dahui Zhao, Jun Xie, Yi Li, Qiang Zeng, Aineng Zeng, Kun Tian, Ruyin Wang, Tianfu Chen, Siping Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits |
title | Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits |
title_full | Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits |
title_fullStr | Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits |
title_full_unstemmed | Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits |
title_short | Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits |
title_sort | ultrasound microbubbles enhance the neuroprotective effect of mouse nerve growth factor on intraocular hypertension-induced neuroretina damage in rabbits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138486/ https://www.ncbi.nlm.nih.gov/pubmed/27994883 http://dx.doi.org/10.1155/2016/4235923 |
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