Cargando…

Limited HIV-1 Reactivation in Resting CD4(+) T cells from Aviremic Patients under Protease Inhibitors

A latent viral reservoir that resides in resting CD4(+) T cells represents a major barrier for eradication of HIV infection. We test here the impact of HIV protease inhibitor (PI) based combination anti-retroviral therapy (cART) over nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Amit, Abbas, Wasim, Bouchat, Sophie, Gatot, Jean-Stéphane, Pasquereau, Sébastien, Kabeya, Kabamba, Clumeck, Nathan, De Wit, Stéphane, Van Lint, Carine, Herbein, Georges
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138822/ https://www.ncbi.nlm.nih.gov/pubmed/27922055 http://dx.doi.org/10.1038/srep38313

Ejemplares similares

Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line
por: Kumar, Amit, et al.
Publicado: (2016)

Counteracting Akt Activation by HIV Protease Inhibitors in Monocytes/Macrophages
por: Pasquereau, Sébastien, et al.
Publicado: (2018)

Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1
por: Bouchat, Sophie, et al.
Publicado: (2015)

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression
por: Darcis, Gilles, et al.
Publicado: (2015)

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection
por: Reuse, Sophie, et al.
Publicado: (2009)

Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs
por: Pasquereau, Sébastien, et al.
Publicado: (2017)

CounterAKTing HIV: Toward a “Block and Clear” Strategy?
por: Pasquereau, Sébastien, et al.
Publicado: (2022)

Ferulic acid derivatives block coronaviruses HCoV-229E and SARS-CoV-2 replication in vitro
por: Pasquereau, Sébastien, et al.
Publicado: (2022)

Epigenetic control of HIV-1 post integration latency: implications for therapy
por: Kumar, Amit, et al.
Publicado: (2015)

Control of viral infections by epigenetic-targeted therapy
por: Nehme, Zeina, et al.
Publicado: (2019)

Targeting histone epigenetics to control viral infections
por: Nehme, Zeina, et al.
Publicado: (2020)

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients
por: Spina, Celsa A., et al.
Publicado: (2013)

TNF and TNF Receptor Superfamily Members in HIV infection: New Cellular Targets for Therapy?
por: Kumar, Amit, et al.
Publicado: (2013)

HIV-1 Latency in Monocytes/Macrophages
por: Kumar, Amit, et al.
Publicado: (2014)

The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections
por: Abbas, Wasim, et al.
Publicado: (2015)

HIV-1 transcription and latency: an update
por: Van Lint, Carine, et al.
Publicado: (2013)

T-Cell Signaling in HIV-1 Infection
por: Abbas, Wasim, et al.
Publicado: (2013)

Polyploid giant cancer cells, EZH2 and Myc upregulation in mammary epithelial cells infected with high-risk human cytomegalovirus
por: Nehme, Zeina, et al.
Publicado: (2022)

Eradication of HIV-1 from the Macrophage Reservoir: An Uncertain Goal?
por: Abbas, Wasim, et al.
Publicado: (2015)

Tumor control by human cytomegalovirus in a murine model of hepatocellular carcinoma
por: Kumar, Amit, et al.
Publicado: (2016)

The transcriptome of human mammary epithelial cells infected with the HCMV-DB strain displays oncogenic traits
por: Moussawi, Fatima Al, et al.
Publicado: (2018)

The HIV-1 Nef Protein Interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA
por: Abbas, Wasim, et al.
Publicado: (2012)

Oncogenic and Stemness Signatures of the High-Risk HCMV Strains in Breast Cancer Progression
por: El Baba, Ranim, et al.
Publicado: (2022)

HCMV Activates the IL-6-JAK-STAT3 Axis in HepG2 Cells and Primary Human Hepatocytes
por: Lepiller, Quentin, et al.
Publicado: (2013)

Correction: HCMV Activates the IL-6-JAK-STAT3 Axis in HepG2 Cells and Primary Human Hepatocytes
por: Lepiller, Quentin, et al.
Publicado: (2013)

Cellular Activation and Intracellular HCV Load in Peripheral Blood Monocytes Isolated from HCV Monoinfected and HIV-HCV Coinfected Patients
por: Dichamp, Isabelle, et al.
Publicado: (2014)

Distinct Oncogenic Transcriptomes in Human Mammary Epithelial Cells Infected With Cytomegalovirus
por: Haidar Ahmad, Sandy, et al.
Publicado: (2021)

The Human Cytomegalovirus Strain DB Activates Oncogenic Pathways in Mammary Epithelial Cells
por: Kumar, Amit, et al.
Publicado: (2018)

Is Kidney Donor Profile Index (KDPI) Valid for Hepatitis C Aviremic Kidneys?
por: Sibulesky, Lena, et al.
Publicado: (2017)

First-line antiretroviral therapy with nevirapine versus lopinavir-ritonavir based regimens in a resource-limited setting
por: Clumeck, Nathan, et al.
Publicado: (2014)

EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes
por: El Baba, Ranim, et al.
Publicado: (2023)

Macrophage signaling in HIV-1 infection
por: Herbein, Georges, et al.
Publicado: (2010)

The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity
por: Vandehout, Nathalie, et al.
Publicado: (2009)

Transcriptional and Immunologic Correlates of Response to Pandemic Influenza Vaccine in Aviremic, HIV-Infected Children
por: de Armas, Lesley R., et al.
Publicado: (2021)

Multimodal Investigation of Neuroinflammation in Aviremic Patients With HIV on Antiretroviral Therapy and HIV Elite Controllers
por: Sari, Hasan, et al.
Publicado: (2022)

Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1
por: Katto, Judith, et al.
Publicado: (2013)

CD4(+) T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection
por: Buggert, Marcus, et al.
Publicado: (2016)

Characteristics of non-AIDS-defining malignancies in the HAART era: a clinico-epidemiological study
por: Dauby, Nicolas, et al.
Publicado: (2011)

LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing
por: Le Douce, Valentin, et al.
Publicado: (2012)

LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing
por: Douce, Valentin Le, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_torgcshggfcshos5o7lpir8q3j