Targeted drug delivery of near IR fluorescent doxorubicin-conjugated poly(ethylene glycol) bisphosphonate nanoparticles for diagnosis and therapy of primary and metastatic bone cancer in a mouse model

BACKGROUND: Most primary and metastatic bone tumors demonstrate increased osteoclast activity and bone resorption. Current treatment is based on a combination of surgery, radiotherapy and chemotherapy. Severe side effects are associated with chemotherapy due to use of high dosage and nonspecific upt...

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Detalles Bibliográficos
Autores principales: Rudnick-Glick, S., Corem-Salkmon, E., Grinberg, I., Margel, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139040/
https://www.ncbi.nlm.nih.gov/pubmed/27919267
http://dx.doi.org/10.1186/s12951-016-0233-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139040/
https://www.ncbi.nlm.nih.gov/pubmed/27919267
http://dx.doi.org/10.1186/s12951-016-0233-6

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