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The Use of Ratiometric Fluorescence Measurements of the Voltage Sensitive Dye Di-4-ANEPPS to Examine Action Potential Characteristics and Drug Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and higher throughput platforms have emerged as potential tools to advance cardiac drug safety screening. This study evaluated the use of high bandwidth photometry applied to voltage-sensitive fluorescent dyes (VSDs) to assess dru...

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Detalles Bibliográficos
Autores principales:	Hortigon-Vinagre, M. P., Zamora, V., Burton, F. L., Green, J., Gintant, G. A., Smith, G. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Voltage-Sensitive Dyes in Human iPSC-Derived Cardiomyocytes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139069/ https://www.ncbi.nlm.nih.gov/pubmed/27621282 http://dx.doi.org/10.1093/toxsci/kfw171

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