Transient Proteotoxicity of Bacterial Virulence Factor Pyocyanin in Renal Tubular Epithelial Cells Induces ER-Related Vacuolation and Can Be Efficiently Modulated by Iron Chelators

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Persistent infections of biofilm forming bacteria, such as Pseudomonas aeruginosa, are common among human populations, due to the bacterial resistance to antibiotics and other adaptation strategies, including release of cytotoxic virulent factors such as pigment pyocyanin (PCN). Urinary tract infect...

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Detalles Bibliográficos
Autores principales: Mossine, Valeri V., Waters, James K., Chance, Deborah L., Mawhinney, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Bacterial Virulence Factor Pyocyanin Effects on Renal Epithelial Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139071/
https://www.ncbi.nlm.nih.gov/pubmed/27613716
http://dx.doi.org/10.1093/toxsci/kfw174
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