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Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva

PURPOSE: To evaluate the histopathologic changes in the conjunctiva of patients with conjunctivochalasis (CCh) compared to age-matched controls. METHODS: This cross-sectional, controlled study included 27 eyes of 27 patients with CCh and 16 eyes of 16 age-matched controls. A biopsy of the bulbar con...

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Autores principales: Hashemian, Hesam, Mahbod, Mirgholamreza, Amoli, Fahimeh A., Kiarudi, Mohammad Y., Jabbarvand, Mahmoud, Kheirkhah, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139544/
https://www.ncbi.nlm.nih.gov/pubmed/27994801
http://dx.doi.org/10.4103/2008-322X.194068
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author Hashemian, Hesam
Mahbod, Mirgholamreza
Amoli, Fahimeh A.
Kiarudi, Mohammad Y.
Jabbarvand, Mahmoud
Kheirkhah, Ahmad
author_facet Hashemian, Hesam
Mahbod, Mirgholamreza
Amoli, Fahimeh A.
Kiarudi, Mohammad Y.
Jabbarvand, Mahmoud
Kheirkhah, Ahmad
author_sort Hashemian, Hesam
collection PubMed
description PURPOSE: To evaluate the histopathologic changes in the conjunctiva of patients with conjunctivochalasis (CCh) compared to age-matched controls. METHODS: This cross-sectional, controlled study included 27 eyes of 27 patients with CCh and 16 eyes of 16 age-matched controls. A biopsy of the bulbar conjunctiva was performed along the temporal lower lid margin before cataract surgery in both groups. Histopathologic evaluation of the specimens was done with light microscopy using staining with hematoxylin/eosin, periodic acid Schiff, and van Gieson elastic stain. Various histopathologic features of the conjunctival epithelium and stroma were compared between the two groups. RESULTS: The mean age of patients was 62.4 ± 6.9 years in the CCh group and 65.1 ± 6.3 years in the control group (P = 0.54). No significant differences were noted between the two groups in terms of conjunctival epithelial changes including papillomatosis, epithelial clefts, epithelial goblet cells, or infiltration of inflammatory cells. Mean thickness of the conjunctival stroma was 0.21 ± 0.08 mm in the CCh group and 0.26 ± 0.21 mm in the control group (P = 0.10). For the conjunctival stroma, there were no significant differences between the two groups in terms of elastosis, fibrosis, lymphangiectasia, or infiltration of inflammatory cells. CONCLUSION: No noticeable differences were found in the histopathologic features by light microscopy between eyes with CCh and those of age-matched controls. Therefore, the primary pathology of CCh may not be within the conjunctiva itself. Instead, loose attachment of the conjunctiva to the underlying tissue may be the reason for the redundant folds in the bulbar conjunctiva.
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spelling pubmed-51395442016-12-19 Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva Hashemian, Hesam Mahbod, Mirgholamreza Amoli, Fahimeh A. Kiarudi, Mohammad Y. Jabbarvand, Mahmoud Kheirkhah, Ahmad J Ophthalmic Vis Res Original Article PURPOSE: To evaluate the histopathologic changes in the conjunctiva of patients with conjunctivochalasis (CCh) compared to age-matched controls. METHODS: This cross-sectional, controlled study included 27 eyes of 27 patients with CCh and 16 eyes of 16 age-matched controls. A biopsy of the bulbar conjunctiva was performed along the temporal lower lid margin before cataract surgery in both groups. Histopathologic evaluation of the specimens was done with light microscopy using staining with hematoxylin/eosin, periodic acid Schiff, and van Gieson elastic stain. Various histopathologic features of the conjunctival epithelium and stroma were compared between the two groups. RESULTS: The mean age of patients was 62.4 ± 6.9 years in the CCh group and 65.1 ± 6.3 years in the control group (P = 0.54). No significant differences were noted between the two groups in terms of conjunctival epithelial changes including papillomatosis, epithelial clefts, epithelial goblet cells, or infiltration of inflammatory cells. Mean thickness of the conjunctival stroma was 0.21 ± 0.08 mm in the CCh group and 0.26 ± 0.21 mm in the control group (P = 0.10). For the conjunctival stroma, there were no significant differences between the two groups in terms of elastosis, fibrosis, lymphangiectasia, or infiltration of inflammatory cells. CONCLUSION: No noticeable differences were found in the histopathologic features by light microscopy between eyes with CCh and those of age-matched controls. Therefore, the primary pathology of CCh may not be within the conjunctiva itself. Instead, loose attachment of the conjunctiva to the underlying tissue may be the reason for the redundant folds in the bulbar conjunctiva. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5139544/ /pubmed/27994801 http://dx.doi.org/10.4103/2008-322X.194068 Text en Copyright: © 2016 Journal of Ophthalmic and Vision Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Hashemian, Hesam
Mahbod, Mirgholamreza
Amoli, Fahimeh A.
Kiarudi, Mohammad Y.
Jabbarvand, Mahmoud
Kheirkhah, Ahmad
Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva
title Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva
title_full Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva
title_fullStr Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva
title_full_unstemmed Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva
title_short Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva
title_sort histopathology of conjunctivochalasis compared to normal conjunctiva
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139544/
https://www.ncbi.nlm.nih.gov/pubmed/27994801
http://dx.doi.org/10.4103/2008-322X.194068
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