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A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis

Hypereosinophilic syndrome (HES) is defined by elevation more than 1.5×10(9)/L of presence of a peripheral blood count, evidence of organ involvement, and exclusion of secondary eosinophilia such as allergic, vasculitis, drugs, or parasite infection and also clonal eosinophilia. We present the HES c...

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Autores principales: Ikeda, Hiroko, Katayanagi, Kazuyoshi, Kurumaya, Hiroshi, Harada, Kenichi, sato, Yasunori, Sasaki, Motoko, Nakanuma, Yasuni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139729/
https://www.ncbi.nlm.nih.gov/pubmed/27942335
http://dx.doi.org/10.4021/gr336e
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author Ikeda, Hiroko
Katayanagi, Kazuyoshi
Kurumaya, Hiroshi
Harada, Kenichi
sato, Yasunori
Sasaki, Motoko
Nakanuma, Yasuni
author_facet Ikeda, Hiroko
Katayanagi, Kazuyoshi
Kurumaya, Hiroshi
Harada, Kenichi
sato, Yasunori
Sasaki, Motoko
Nakanuma, Yasuni
author_sort Ikeda, Hiroko
collection PubMed
description Hypereosinophilic syndrome (HES) is defined by elevation more than 1.5×10(9)/L of presence of a peripheral blood count, evidence of organ involvement, and exclusion of secondary eosinophilia such as allergic, vasculitis, drugs, or parasite infection and also clonal eosinophilia. We present the HES case with hepatic involvement. The patient is 70-year-old male. He complained fever and back pain. Blood examination showed marked peripheral eosinophilia, elevation of transaminase and biliary enzymes. Multiple irregular mass lesions of the liver were pointed out by CT and MRI. The liver biopsy was done for differentiation from malignancy. In parenchyma, hepatic necrotic lesion was observed accompanying severe eosinophilic infiltration with Charcot-Leyden’s crystals. There was granulomatous reaction. He was diagnosed as HES and got recovery due to steroid therapy. From the review of HES article, the hepatic histology is categorized into four types as below: 1) cholangitis type; 2) chronic active hepatitis type; 3) vasculopathic type, 4) hepatic necrosis type. Our case is classified in hepatic necrosis type. This type seems to be important to distinguish malignant tumor and also visceral larva migrans by liver biopsy.
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spelling pubmed-51397292016-12-09 A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis Ikeda, Hiroko Katayanagi, Kazuyoshi Kurumaya, Hiroshi Harada, Kenichi sato, Yasunori Sasaki, Motoko Nakanuma, Yasuni Gastroenterology Res Case Report Hypereosinophilic syndrome (HES) is defined by elevation more than 1.5×10(9)/L of presence of a peripheral blood count, evidence of organ involvement, and exclusion of secondary eosinophilia such as allergic, vasculitis, drugs, or parasite infection and also clonal eosinophilia. We present the HES case with hepatic involvement. The patient is 70-year-old male. He complained fever and back pain. Blood examination showed marked peripheral eosinophilia, elevation of transaminase and biliary enzymes. Multiple irregular mass lesions of the liver were pointed out by CT and MRI. The liver biopsy was done for differentiation from malignancy. In parenchyma, hepatic necrotic lesion was observed accompanying severe eosinophilic infiltration with Charcot-Leyden’s crystals. There was granulomatous reaction. He was diagnosed as HES and got recovery due to steroid therapy. From the review of HES article, the hepatic histology is categorized into four types as below: 1) cholangitis type; 2) chronic active hepatitis type; 3) vasculopathic type, 4) hepatic necrosis type. Our case is classified in hepatic necrosis type. This type seems to be important to distinguish malignant tumor and also visceral larva migrans by liver biopsy. Elmer Press 2011-08 2011-07-20 /pmc/articles/PMC5139729/ /pubmed/27942335 http://dx.doi.org/10.4021/gr336e Text en Copyright 2011, Ikeda et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ikeda, Hiroko
Katayanagi, Kazuyoshi
Kurumaya, Hiroshi
Harada, Kenichi
sato, Yasunori
Sasaki, Motoko
Nakanuma, Yasuni
A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis
title A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis
title_full A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis
title_fullStr A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis
title_full_unstemmed A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis
title_short A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis
title_sort case of hypereosinophilia-associated multiple mass lesions of liver showing non-granulomatous eosinophilic hepatic necrosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139729/
https://www.ncbi.nlm.nih.gov/pubmed/27942335
http://dx.doi.org/10.4021/gr336e
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