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Small Duct Primary Sclerosing Cholangitis in Association With Hepatitis C Virus Infection: A Case Report
Small duct primary sclerosing cholangitis (PSC) is characterized by cholestatic liver function tests, histological evidence of PSC but absence of classic cholangiographic findings. Large duct or classic PSC in association with hepatitis C virus (HCV) infection has rarely been reported. However to th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139801/ https://www.ncbi.nlm.nih.gov/pubmed/27957013 http://dx.doi.org/10.4021/gr282w |
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author | Nayudu, Suresh Kumar Kumbum, Kavitha Balar, Bhavna Niazi, Masooma Chilimuri, Sridhar |
author_facet | Nayudu, Suresh Kumar Kumbum, Kavitha Balar, Bhavna Niazi, Masooma Chilimuri, Sridhar |
author_sort | Nayudu, Suresh Kumar |
collection | PubMed |
description | Small duct primary sclerosing cholangitis (PSC) is characterized by cholestatic liver function tests, histological evidence of PSC but absence of classic cholangiographic findings. Large duct or classic PSC in association with hepatitis C virus (HCV) infection has rarely been reported. However to the best of our knowledge small duct PSC in association with HCV infection has not been reported. We report this case of small duct PSC in a patient with HCV infection. HCV infection in our patient was successfully treated with ribavirin and peg interferon alfa-2a, as evidenced by undetectable HCV ribonucleic acid levels. However, the patient had persistently elevated liver function tests suggestive of cholestasis. Endoscopic retrograde cholangiopancreatography (ERCP) revealed normal architecture of bile ducts. Hence patient underwent liver biopsy and its histopahological findings were suggestive of PSC. He had colonoscopy along with biopsy and inflammatory bowel disease (IBD) was ruled out. |
format | Online Article Text |
id | pubmed-5139801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51398012016-12-12 Small Duct Primary Sclerosing Cholangitis in Association With Hepatitis C Virus Infection: A Case Report Nayudu, Suresh Kumar Kumbum, Kavitha Balar, Bhavna Niazi, Masooma Chilimuri, Sridhar Gastroenterology Res Case Report Small duct primary sclerosing cholangitis (PSC) is characterized by cholestatic liver function tests, histological evidence of PSC but absence of classic cholangiographic findings. Large duct or classic PSC in association with hepatitis C virus (HCV) infection has rarely been reported. However to the best of our knowledge small duct PSC in association with HCV infection has not been reported. We report this case of small duct PSC in a patient with HCV infection. HCV infection in our patient was successfully treated with ribavirin and peg interferon alfa-2a, as evidenced by undetectable HCV ribonucleic acid levels. However, the patient had persistently elevated liver function tests suggestive of cholestasis. Endoscopic retrograde cholangiopancreatography (ERCP) revealed normal architecture of bile ducts. Hence patient underwent liver biopsy and its histopahological findings were suggestive of PSC. He had colonoscopy along with biopsy and inflammatory bowel disease (IBD) was ruled out. Elmer Press 2011-02 2011-01-20 /pmc/articles/PMC5139801/ /pubmed/27957013 http://dx.doi.org/10.4021/gr282w Text en Copyright 2011, Nayudu et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Nayudu, Suresh Kumar Kumbum, Kavitha Balar, Bhavna Niazi, Masooma Chilimuri, Sridhar Small Duct Primary Sclerosing Cholangitis in Association With Hepatitis C Virus Infection: A Case Report |
title | Small Duct Primary Sclerosing Cholangitis in Association With Hepatitis C Virus Infection: A Case Report |
title_full | Small Duct Primary Sclerosing Cholangitis in Association With Hepatitis C Virus Infection: A Case Report |
title_fullStr | Small Duct Primary Sclerosing Cholangitis in Association With Hepatitis C Virus Infection: A Case Report |
title_full_unstemmed | Small Duct Primary Sclerosing Cholangitis in Association With Hepatitis C Virus Infection: A Case Report |
title_short | Small Duct Primary Sclerosing Cholangitis in Association With Hepatitis C Virus Infection: A Case Report |
title_sort | small duct primary sclerosing cholangitis in association with hepatitis c virus infection: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139801/ https://www.ncbi.nlm.nih.gov/pubmed/27957013 http://dx.doi.org/10.4021/gr282w |
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