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Inactivation of Digestive Proteases by Deconjugated Bilirubin and the Physiological Significance of Fasting Hyperbilirubinemia
It has been observed more than a century ago that in humans as well as in many animals, there was a significantly increase in blood bilirubin level during fasting. However, the physiological significance for this increase remains largely unknown. As it is found that digestive proteases are inactivat...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elmer Press
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139891/ https://www.ncbi.nlm.nih.gov/pubmed/27956956 http://dx.doi.org/10.4021/gr2009.02.1270 |
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author | Qin, Xiaofa |
author_facet | Qin, Xiaofa |
author_sort | Qin, Xiaofa |
collection | PubMed |
description | It has been observed more than a century ago that in humans as well as in many animals, there was a significantly increase in blood bilirubin level during fasting. However, the physiological significance for this increase remains largely unknown. As it is found that digestive proteases are inactivated by free (or deconjugated) bilirubin, here I suggested that fasting hyperbilirubinemia would be a mechanism to save bilirubin during fasting to meet the anticipated increased needs to protect the gut against the damage by the increased luminal pancreatic proteases during and after feeding. |
format | Online Article Text |
id | pubmed-5139891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51398912016-12-12 Inactivation of Digestive Proteases by Deconjugated Bilirubin and the Physiological Significance of Fasting Hyperbilirubinemia Qin, Xiaofa Gastroenterology Res Letter to the Editor It has been observed more than a century ago that in humans as well as in many animals, there was a significantly increase in blood bilirubin level during fasting. However, the physiological significance for this increase remains largely unknown. As it is found that digestive proteases are inactivated by free (or deconjugated) bilirubin, here I suggested that fasting hyperbilirubinemia would be a mechanism to save bilirubin during fasting to meet the anticipated increased needs to protect the gut against the damage by the increased luminal pancreatic proteases during and after feeding. Elmer Press 2009-02 2009-01-20 /pmc/articles/PMC5139891/ /pubmed/27956956 http://dx.doi.org/10.4021/gr2009.02.1270 Text en Copyright 2009, Qin http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Letter to the Editor Qin, Xiaofa Inactivation of Digestive Proteases by Deconjugated Bilirubin and the Physiological Significance of Fasting Hyperbilirubinemia |
title | Inactivation of Digestive Proteases by Deconjugated Bilirubin and the Physiological Significance of Fasting Hyperbilirubinemia |
title_full | Inactivation of Digestive Proteases by Deconjugated Bilirubin and the Physiological Significance of Fasting Hyperbilirubinemia |
title_fullStr | Inactivation of Digestive Proteases by Deconjugated Bilirubin and the Physiological Significance of Fasting Hyperbilirubinemia |
title_full_unstemmed | Inactivation of Digestive Proteases by Deconjugated Bilirubin and the Physiological Significance of Fasting Hyperbilirubinemia |
title_short | Inactivation of Digestive Proteases by Deconjugated Bilirubin and the Physiological Significance of Fasting Hyperbilirubinemia |
title_sort | inactivation of digestive proteases by deconjugated bilirubin and the physiological significance of fasting hyperbilirubinemia |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139891/ https://www.ncbi.nlm.nih.gov/pubmed/27956956 http://dx.doi.org/10.4021/gr2009.02.1270 |
work_keys_str_mv | AT qinxiaofa inactivationofdigestiveproteasesbydeconjugatedbilirubinandthephysiologicalsignificanceoffastinghyperbilirubinemia |