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Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts
Respiratory infections are a major cause of pulmonary decline in children with cystic fibrosis (CF). We compared the prevalence of infection in early life at geographically distant CF treatment centres participating in the same surveillance programme in Australia. Lower airway microbiology, inflamma...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140014/ https://www.ncbi.nlm.nih.gov/pubmed/27957481 http://dx.doi.org/10.1183/23120541.00014-2016 |
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author | Ramsey, Kathryn A. Hart, Emily Turkovic, Lidija Padros-Goossens, Marc Stick, Stephen M. Ranganathan, Sarath C. |
author_facet | Ramsey, Kathryn A. Hart, Emily Turkovic, Lidija Padros-Goossens, Marc Stick, Stephen M. Ranganathan, Sarath C. |
author_sort | Ramsey, Kathryn A. |
collection | PubMed |
description | Respiratory infections are a major cause of pulmonary decline in children with cystic fibrosis (CF). We compared the prevalence of infection in early life at geographically distant CF treatment centres participating in the same surveillance programme in Australia. Lower airway microbiology, inflammation and structural lung disease at annual review were evaluated for 260 children 0–8 years old with CF at 1032 visits to CF treatment centres in Melbourne or Perth. Melbourne patients were more likely to be culture-positive for common respiratory pathogens at all age groups (odds ratio (OR) 1.85, 95% CI 1.33–2.58). Subjects <2 years old in Melbourne were also more likely to have neutrophil elastase present (OR 3.11, 95% CI 1.62–5.95). Bronchiectasis (OR 2.02, 95% CI 1.21–3.38) and air trapping (OR 2.53, 95% CI 1.42–4.51) in subjects 2–5 years old was more common in Melbourne subjects. The severity of structural lung disease was also worse in Melbourne patients >5 years old. Patients at both centres had a similar rate of hospitalisations and prescribed antibiotics. No procedural differences were identified that could explain the disparity between pathogen prevalence. Geographical differences in early acquisition of infection may contribute to variability in outcomes between CF centres. |
format | Online Article Text |
id | pubmed-5140014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-51400142016-12-12 Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts Ramsey, Kathryn A. Hart, Emily Turkovic, Lidija Padros-Goossens, Marc Stick, Stephen M. Ranganathan, Sarath C. ERJ Open Res Original Articles Respiratory infections are a major cause of pulmonary decline in children with cystic fibrosis (CF). We compared the prevalence of infection in early life at geographically distant CF treatment centres participating in the same surveillance programme in Australia. Lower airway microbiology, inflammation and structural lung disease at annual review were evaluated for 260 children 0–8 years old with CF at 1032 visits to CF treatment centres in Melbourne or Perth. Melbourne patients were more likely to be culture-positive for common respiratory pathogens at all age groups (odds ratio (OR) 1.85, 95% CI 1.33–2.58). Subjects <2 years old in Melbourne were also more likely to have neutrophil elastase present (OR 3.11, 95% CI 1.62–5.95). Bronchiectasis (OR 2.02, 95% CI 1.21–3.38) and air trapping (OR 2.53, 95% CI 1.42–4.51) in subjects 2–5 years old was more common in Melbourne subjects. The severity of structural lung disease was also worse in Melbourne patients >5 years old. Patients at both centres had a similar rate of hospitalisations and prescribed antibiotics. No procedural differences were identified that could explain the disparity between pathogen prevalence. Geographical differences in early acquisition of infection may contribute to variability in outcomes between CF centres. European Respiratory Society 2016-09-26 /pmc/articles/PMC5140014/ /pubmed/27957481 http://dx.doi.org/10.1183/23120541.00014-2016 Text en The content of this work is copyright of the authors or their employers. Design and branding are copyright ©ERS 2016 http://creativecommons.org/licenses/by-nc/4.0/ This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Original Articles Ramsey, Kathryn A. Hart, Emily Turkovic, Lidija Padros-Goossens, Marc Stick, Stephen M. Ranganathan, Sarath C. Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts |
title | Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts |
title_full | Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts |
title_fullStr | Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts |
title_full_unstemmed | Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts |
title_short | Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts |
title_sort | respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140014/ https://www.ncbi.nlm.nih.gov/pubmed/27957481 http://dx.doi.org/10.1183/23120541.00014-2016 |
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