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The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems

We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many models of complex biological processes it is unknown what...

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Detalles Bibliográficos
Autores principales:	White, Andrew, Tolman, Malachi, Thames, Howard D., Withers, Hubert Rodney, Mason, Kathy A., Transtrum, Mark K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140062/ https://www.ncbi.nlm.nih.gov/pubmed/27923060 http://dx.doi.org/10.1371/journal.pcbi.1005227

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