Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response

The utility of tumor-derived cell lines is dependent on their ability to recapitulate underlying genomic aberrations and primary tumor biology. Here, we sequenced the exomes of 25 bladder cancer (BCa) cell lines and compared mutations, copy number alterations (CNAs), gene expression and drug respons...

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Detalles Bibliográficos
Autores principales: Nickerson, M L, Witte, N, Im, K M, Turan, S, Owens, C, Misner, K, Tsang, S X, Cai, Z, Wu, S, Dean, M, Costello, J C, Theodorescu, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140783/
https://www.ncbi.nlm.nih.gov/pubmed/27270441
http://dx.doi.org/10.1038/onc.2016.172

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