Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus

We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated s...

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Autores principales: Sekiguchi, Kenji, Yasui, Naoko, Kowa, Hisatomo, Kanda, Fumio, Toda, Tatsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140871/
https://www.ncbi.nlm.nih.gov/pubmed/27803416
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author Sekiguchi, Kenji
Yasui, Naoko
Kowa, Hisatomo
Kanda, Fumio
Toda, Tatsushi
author_facet Sekiguchi, Kenji
Yasui, Naoko
Kowa, Hisatomo
Kanda, Fumio
Toda, Tatsushi
author_sort Sekiguchi, Kenji
collection PubMed
description We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.
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spelling pubmed-51408712016-12-12 Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus Sekiguchi, Kenji Yasui, Naoko Kowa, Hisatomo Kanda, Fumio Toda, Tatsushi Intern Med Case Report We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination. The Japanese Society of Internal Medicine 2016-11-01 /pmc/articles/PMC5140871/ /pubmed/27803416 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sekiguchi, Kenji
Yasui, Naoko
Kowa, Hisatomo
Kanda, Fumio
Toda, Tatsushi
Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus
title Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus
title_full Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus
title_fullStr Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus
title_full_unstemmed Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus
title_short Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus
title_sort two cases of acute disseminated encephalomyelitis following vaccination against human papilloma virus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140871/
https://www.ncbi.nlm.nih.gov/pubmed/27803416
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