Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis

A 49-year-old female was referred to our hospital due to high serum creatine kinase (CK) (2,605 IU/L) and serum cardiac troponin T (cTnT) (0.342 ng/mL) levels. She had no other complaints and further examinations suggested no signs of cardiac disease. Additionally, the serum cardiac troponin I (cTnI...

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Autores principales: Mannoji, Hiroshi, Hayashi, Fumie, Kubota, Toru, Ikeda, Yoshihiko, Ishibashi-Ueda, Hatsue, Kato, Seiya, Tahara, Nobuhiro, Fukutomi, Takayoshi, Yamada, Takeshi, Okabe, Masanori, Yamamoto, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140878/
https://www.ncbi.nlm.nih.gov/pubmed/27803423
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author Mannoji, Hiroshi
Hayashi, Fumie
Kubota, Toru
Ikeda, Yoshihiko
Ishibashi-Ueda, Hatsue
Kato, Seiya
Tahara, Nobuhiro
Fukutomi, Takayoshi
Yamada, Takeshi
Okabe, Masanori
Yamamoto, Yusuke
author_facet Mannoji, Hiroshi
Hayashi, Fumie
Kubota, Toru
Ikeda, Yoshihiko
Ishibashi-Ueda, Hatsue
Kato, Seiya
Tahara, Nobuhiro
Fukutomi, Takayoshi
Yamada, Takeshi
Okabe, Masanori
Yamamoto, Yusuke
author_sort Mannoji, Hiroshi
collection PubMed
description A 49-year-old female was referred to our hospital due to high serum creatine kinase (CK) (2,605 IU/L) and serum cardiac troponin T (cTnT) (0.342 ng/mL) levels. She had no other complaints and further examinations suggested no signs of cardiac disease. Additionally, the serum cardiac troponin I (cTnI) levels were normal. She reported having gradually felt difficulty in walking upstairs. A biopsy indicated skeletal muscle sarcoidosis with positive staining for cTnT. Steroid therapy immediately resolved her muscular symptoms with a normalization of the serum CK levels. Since the serum levels of cTnI were normal, the concomitant measurement of cTnT/cTnI might be useful to diagnose skeletal muscular disease biochemically in such cases.
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spelling pubmed-51408782016-12-12 Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis Mannoji, Hiroshi Hayashi, Fumie Kubota, Toru Ikeda, Yoshihiko Ishibashi-Ueda, Hatsue Kato, Seiya Tahara, Nobuhiro Fukutomi, Takayoshi Yamada, Takeshi Okabe, Masanori Yamamoto, Yusuke Intern Med Case Report A 49-year-old female was referred to our hospital due to high serum creatine kinase (CK) (2,605 IU/L) and serum cardiac troponin T (cTnT) (0.342 ng/mL) levels. She had no other complaints and further examinations suggested no signs of cardiac disease. Additionally, the serum cardiac troponin I (cTnI) levels were normal. She reported having gradually felt difficulty in walking upstairs. A biopsy indicated skeletal muscle sarcoidosis with positive staining for cTnT. Steroid therapy immediately resolved her muscular symptoms with a normalization of the serum CK levels. Since the serum levels of cTnI were normal, the concomitant measurement of cTnT/cTnI might be useful to diagnose skeletal muscular disease biochemically in such cases. The Japanese Society of Internal Medicine 2016-11-01 /pmc/articles/PMC5140878/ /pubmed/27803423 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Mannoji, Hiroshi
Hayashi, Fumie
Kubota, Toru
Ikeda, Yoshihiko
Ishibashi-Ueda, Hatsue
Kato, Seiya
Tahara, Nobuhiro
Fukutomi, Takayoshi
Yamada, Takeshi
Okabe, Masanori
Yamamoto, Yusuke
Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis
title Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis
title_full Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis
title_fullStr Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis
title_full_unstemmed Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis
title_short Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis
title_sort differential expression of cardiac troponin t and i in a patient with isolated skeletal muscular sarcoidosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140878/
https://www.ncbi.nlm.nih.gov/pubmed/27803423
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