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Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran
BACKGROUND: Single-nucleotide polymorphism (SNP) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (PTPN22) has been shown to be a risk factor for different autoimmune diseases. This study explored the association of 1858 C/T SNP with rheumatoid arthritis (RA) and celiac diseas...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pasteur Institute
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141256/ https://www.ncbi.nlm.nih.gov/pubmed/27215233 http://dx.doi.org/10.6091/.21.1.61 |
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author | Abbasi, Zahra Nezhad, Seyed Reza Kazemi Pourmahdi-Broojeni, Mahdi Rajaei, Elham |
author_facet | Abbasi, Zahra Nezhad, Seyed Reza Kazemi Pourmahdi-Broojeni, Mahdi Rajaei, Elham |
author_sort | Abbasi, Zahra |
collection | PubMed |
description | BACKGROUND: Single-nucleotide polymorphism (SNP) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (PTPN22) has been shown to be a risk factor for different autoimmune diseases. This study explored the association of 1858 C/T SNP with rheumatoid arthritis (RA) and celiac disease (CD) in a region covering south-west of Iran. METHODS: Totally, 52 patients with CD, 120 patients with RA, and 120 healthy subjects were selected. The samples were genotyped for the rs2476601 in PTPN22 gene using the tetra-amplification refractory mutation system polymerase chain reaction. RESULTS: The frequency of +1858T risk allele was significantly increased in both RA (P=0.021, OR=2.56, 95%CI=1.19-5.47) and CD (P=0.002, OR=3.87, 95%CI=1.68-8.95) patients, as compared to the control group. However, no association was found between the +1858C/T PTPN22 gene SNP and the anti-cyclic citrullinated peptide and rheumatoid factor positivity in RA patients. CONCLUSIONS: PTPN22 gene could play a crucial role in people’s susceptibility to certain autoimmune diseases. |
format | Online Article Text |
id | pubmed-5141256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Pasteur Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-51412562017-01-01 Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran Abbasi, Zahra Nezhad, Seyed Reza Kazemi Pourmahdi-Broojeni, Mahdi Rajaei, Elham Iran Biomed J Short Communication BACKGROUND: Single-nucleotide polymorphism (SNP) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (PTPN22) has been shown to be a risk factor for different autoimmune diseases. This study explored the association of 1858 C/T SNP with rheumatoid arthritis (RA) and celiac disease (CD) in a region covering south-west of Iran. METHODS: Totally, 52 patients with CD, 120 patients with RA, and 120 healthy subjects were selected. The samples were genotyped for the rs2476601 in PTPN22 gene using the tetra-amplification refractory mutation system polymerase chain reaction. RESULTS: The frequency of +1858T risk allele was significantly increased in both RA (P=0.021, OR=2.56, 95%CI=1.19-5.47) and CD (P=0.002, OR=3.87, 95%CI=1.68-8.95) patients, as compared to the control group. However, no association was found between the +1858C/T PTPN22 gene SNP and the anti-cyclic citrullinated peptide and rheumatoid factor positivity in RA patients. CONCLUSIONS: PTPN22 gene could play a crucial role in people’s susceptibility to certain autoimmune diseases. Pasteur Institute 2017-01 /pmc/articles/PMC5141256/ /pubmed/27215233 http://dx.doi.org/10.6091/.21.1.61 Text en Copyright: © Iranian Biomedical Journal http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Abbasi, Zahra Nezhad, Seyed Reza Kazemi Pourmahdi-Broojeni, Mahdi Rajaei, Elham Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran |
title | Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran |
title_full | Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran |
title_fullStr | Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran |
title_full_unstemmed | Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran |
title_short | Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran |
title_sort | association of ptpn22 rs2476601 polymorphism with rheumatoid arthritis and celiac disease in khuzestan province, southwestern iran |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141256/ https://www.ncbi.nlm.nih.gov/pubmed/27215233 http://dx.doi.org/10.6091/.21.1.61 |
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