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Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer

The gene encoding phosphatidylinositol 3-kinase catalytic subunit α-isoform (PIK3CA, p110α) is frequently activated by mutation in human cancers. Based on detection in some breast cancer precursors, PIK3CA mutations have been proposed to have a role in tumor initiation. To investigate this hypothesi...

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Detalles Bibliográficos
Autores principales:	Sheen, M R, Marotti, J D, Allegrezza, M J, Rutkowski, M, Conejo-Garcia, J R, Fiering, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141269/ https://www.ncbi.nlm.nih.gov/pubmed/27797363 http://dx.doi.org/10.1038/oncsis.2016.65

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