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Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency

A 20-day-old male infant who was born at 39 weeks of gestation was admitted to neonatal intensive care unit due to severe respiratory insufficiency. In retinal examination, peripheric retinal white-black color areas that correspond to necrotizing retinitis, moderate vitritis, macular and optic nerve...

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Autores principales: Ozcan, Pehmen Yasin, Celik, Hasan Tolga, Sonmez, Kenan, Celik, Melda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141320/
https://www.ncbi.nlm.nih.gov/pubmed/27999698
http://dx.doi.org/10.1155/2016/1495639
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author Ozcan, Pehmen Yasin
Celik, Hasan Tolga
Sonmez, Kenan
Celik, Melda
author_facet Ozcan, Pehmen Yasin
Celik, Hasan Tolga
Sonmez, Kenan
Celik, Melda
author_sort Ozcan, Pehmen Yasin
collection PubMed
description A 20-day-old male infant who was born at 39 weeks of gestation was admitted to neonatal intensive care unit due to severe respiratory insufficiency. In retinal examination, peripheric retinal white-black color areas that correspond to necrotizing retinitis, moderate vitritis, macular and optic nerve head involvement, vascular leakage, and sheathing indicating perivasculitis were revealed. Despite the fact that CMV specific IgM was undetectable, CMV DNA with high viral load was found in his blood sample by means of real-time polymerase chain reaction assay. Serologic examination (IgM) for rubella, toxoplasma, herpes simplex type 2, and human immunodeficiency virus (anti-HIV) was negative. During the further evaluation for systemic immune dysfunction, decreased immunoglobulin and lymphocyte levels that confirm the diagnosis of severe combined immunodeficiency have been reached. Although given systemic intravenous ganciclovir and antibiotics treatment, the patient died at the 4th month of life due to respiratory insufficiency.
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spelling pubmed-51413202016-12-20 Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency Ozcan, Pehmen Yasin Celik, Hasan Tolga Sonmez, Kenan Celik, Melda Case Rep Ophthalmol Med Case Report A 20-day-old male infant who was born at 39 weeks of gestation was admitted to neonatal intensive care unit due to severe respiratory insufficiency. In retinal examination, peripheric retinal white-black color areas that correspond to necrotizing retinitis, moderate vitritis, macular and optic nerve head involvement, vascular leakage, and sheathing indicating perivasculitis were revealed. Despite the fact that CMV specific IgM was undetectable, CMV DNA with high viral load was found in his blood sample by means of real-time polymerase chain reaction assay. Serologic examination (IgM) for rubella, toxoplasma, herpes simplex type 2, and human immunodeficiency virus (anti-HIV) was negative. During the further evaluation for systemic immune dysfunction, decreased immunoglobulin and lymphocyte levels that confirm the diagnosis of severe combined immunodeficiency have been reached. Although given systemic intravenous ganciclovir and antibiotics treatment, the patient died at the 4th month of life due to respiratory insufficiency. Hindawi Publishing Corporation 2016 2016-11-23 /pmc/articles/PMC5141320/ /pubmed/27999698 http://dx.doi.org/10.1155/2016/1495639 Text en Copyright © 2016 Pehmen Yasin Ozcan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ozcan, Pehmen Yasin
Celik, Hasan Tolga
Sonmez, Kenan
Celik, Melda
Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency
title Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency
title_full Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency
title_fullStr Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency
title_full_unstemmed Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency
title_short Necrotizing Retinitis Secondary to Congenital Cytomegalovirus Infection Associated with Severe Combined Immunodeficiency
title_sort necrotizing retinitis secondary to congenital cytomegalovirus infection associated with severe combined immunodeficiency
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141320/
https://www.ncbi.nlm.nih.gov/pubmed/27999698
http://dx.doi.org/10.1155/2016/1495639
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