p53-independent ibrutinib responses in an Eμ-TCL1 mouse model demonstrates efficacy in high-risk CLL

Deletion of the short-arm of chromosome 17 (17p-) is one of the most critical genetic alterations used in chronic lymphocytic leukemia (CLL) risk stratification. The tumor suppressor TP53 maps to this region, and its loss or mutation accelerates CLL progression, hampers response to chemotherapy and...

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Detalles Bibliográficos
Autores principales: Lee, H J, Gallardo, M, Ma, H, Zhang, X, Larsson, C A, Mejia, A, Hornbaker, M J, Qi, Y, Su, X, Pageon, L R, Quintas-Cardama, A, Post, S M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141356/
https://www.ncbi.nlm.nih.gov/pubmed/27284738
http://dx.doi.org/10.1038/bcj.2016.41

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