Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

Small heat shock proteins (sHsp) constitute an evolutionary conserved yet diverse family of chaperones acting as first line of defence against proteotoxic stress. sHsps coaggregate with misfolded proteins but the molecular basis and functional implications of these interactions, as well as potential...

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Detalles Bibliográficos
Autores principales: Ungelenk, Sophia, Moayed, Fatemeh, Ho, Chi-Ting, Grousl, Tomas, Scharf, Annette, Mashaghi, Alireza, Tans, Sander, Mayer, Matthias P., Mogk, Axel, Bukau, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141385/
https://www.ncbi.nlm.nih.gov/pubmed/27901028
http://dx.doi.org/10.1038/ncomms13673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141385/
https://www.ncbi.nlm.nih.gov/pubmed/27901028
http://dx.doi.org/10.1038/ncomms13673

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