Cargando…
Increased copeptin levels in metabolic syndrome from a Romanian population
Rationale: Arginine vasopressin (AVP) is secreted under conditions of water deprivation. Since AVP has a low half-life in the plasma, the C-terminal fragment of AVP-precursor (copeptin) was used to estimate the AVP levels. High copeptin levels increase the risk for the development of diabetes mellit...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141393/ https://www.ncbi.nlm.nih.gov/pubmed/27928437 |
_version_ | 1782472604634841088 |
---|---|
author | Vintilă, M Gheorghiu, ML Caragheorgheopol, A Baculescu, N Lichiardopol, C Badiu, C Coculescu, M Grigorescu, F Poiană, C |
author_facet | Vintilă, M Gheorghiu, ML Caragheorgheopol, A Baculescu, N Lichiardopol, C Badiu, C Coculescu, M Grigorescu, F Poiană, C |
author_sort | Vintilă, M |
collection | PubMed |
description | Rationale: Arginine vasopressin (AVP) is secreted under conditions of water deprivation. Since AVP has a low half-life in the plasma, the C-terminal fragment of AVP-precursor (copeptin) was used to estimate the AVP levels. High copeptin levels increase the risk for the development of diabetes mellitus. Aim: This study was aimed to measure copeptin levels in the metabolic syndrome (MetS) in Romanians using a competitive enzyme immunoassay. Methods and results: Patients prone to present MetS (n = 63) were compared to controls (n = 42). In the MetS group, the syndrome was confirmed in 93.6%. Affected patients displayed 85.7% obesity and insulin resistance (HOMAIR of 4.9 ± 0.4 versus 1.1 ± 0.8 in controls). Low HDL-cholesterol was less represented (47.5%). Copeptin levels were 0.6 ± 0.0 in MetS versus 0.42 ± 0.0 ng/ mL in controls (P < 0.004). Higher copeptin (0.79 to 1.83 ng/ mL) was associated with MetS, P < 0.0018, OR 20, 95%CI [3.03 – 131.7]. In ANOVA, high copeptin was equally explained by MetS or obesity (P < 0.05,α = 3.8). The best correlation was found with high triglyceride levels (P < 0.013,α = 6.3) while the correlation with HOMAIR remained not significant. Discussion: These data indicated a concordant correlation between increased copeptin and MetS or its components. In the light of epidemiological data, indicating that more than 50% of the European population has a lower daily water intake and a fraction of 25% displaying high copeptin, our data further sustained that copeptin may be a good biomarker for MetS and/ or obesity, which should be further investigated with other members of the osmoregulation pathway at both pathogenesis and genetic levels. |
format | Online Article Text |
id | pubmed-5141393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51413932016-12-07 Increased copeptin levels in metabolic syndrome from a Romanian population Vintilă, M Gheorghiu, ML Caragheorgheopol, A Baculescu, N Lichiardopol, C Badiu, C Coculescu, M Grigorescu, F Poiană, C J Med Life Original Articles Rationale: Arginine vasopressin (AVP) is secreted under conditions of water deprivation. Since AVP has a low half-life in the plasma, the C-terminal fragment of AVP-precursor (copeptin) was used to estimate the AVP levels. High copeptin levels increase the risk for the development of diabetes mellitus. Aim: This study was aimed to measure copeptin levels in the metabolic syndrome (MetS) in Romanians using a competitive enzyme immunoassay. Methods and results: Patients prone to present MetS (n = 63) were compared to controls (n = 42). In the MetS group, the syndrome was confirmed in 93.6%. Affected patients displayed 85.7% obesity and insulin resistance (HOMAIR of 4.9 ± 0.4 versus 1.1 ± 0.8 in controls). Low HDL-cholesterol was less represented (47.5%). Copeptin levels were 0.6 ± 0.0 in MetS versus 0.42 ± 0.0 ng/ mL in controls (P < 0.004). Higher copeptin (0.79 to 1.83 ng/ mL) was associated with MetS, P < 0.0018, OR 20, 95%CI [3.03 – 131.7]. In ANOVA, high copeptin was equally explained by MetS or obesity (P < 0.05,α = 3.8). The best correlation was found with high triglyceride levels (P < 0.013,α = 6.3) while the correlation with HOMAIR remained not significant. Discussion: These data indicated a concordant correlation between increased copeptin and MetS or its components. In the light of epidemiological data, indicating that more than 50% of the European population has a lower daily water intake and a fraction of 25% displaying high copeptin, our data further sustained that copeptin may be a good biomarker for MetS and/ or obesity, which should be further investigated with other members of the osmoregulation pathway at both pathogenesis and genetic levels. Carol Davila University Press 2016 /pmc/articles/PMC5141393/ /pubmed/27928437 Text en ©Carol Davila University Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Vintilă, M Gheorghiu, ML Caragheorgheopol, A Baculescu, N Lichiardopol, C Badiu, C Coculescu, M Grigorescu, F Poiană, C Increased copeptin levels in metabolic syndrome from a Romanian population |
title | Increased copeptin levels in metabolic syndrome from a Romanian population
|
title_full | Increased copeptin levels in metabolic syndrome from a Romanian population
|
title_fullStr | Increased copeptin levels in metabolic syndrome from a Romanian population
|
title_full_unstemmed | Increased copeptin levels in metabolic syndrome from a Romanian population
|
title_short | Increased copeptin levels in metabolic syndrome from a Romanian population
|
title_sort | increased copeptin levels in metabolic syndrome from a romanian population |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141393/ https://www.ncbi.nlm.nih.gov/pubmed/27928437 |
work_keys_str_mv | AT vintilam increasedcopeptinlevelsinmetabolicsyndromefromaromanianpopulation AT gheorghiuml increasedcopeptinlevelsinmetabolicsyndromefromaromanianpopulation AT caragheorgheopola increasedcopeptinlevelsinmetabolicsyndromefromaromanianpopulation AT baculescun increasedcopeptinlevelsinmetabolicsyndromefromaromanianpopulation AT lichiardopolc increasedcopeptinlevelsinmetabolicsyndromefromaromanianpopulation AT badiuc increasedcopeptinlevelsinmetabolicsyndromefromaromanianpopulation AT coculescum increasedcopeptinlevelsinmetabolicsyndromefromaromanianpopulation AT grigorescuf increasedcopeptinlevelsinmetabolicsyndromefromaromanianpopulation AT poianac increasedcopeptinlevelsinmetabolicsyndromefromaromanianpopulation |