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Increased copeptin levels in metabolic syndrome from a Romanian population

Rationale: Arginine vasopressin (AVP) is secreted under conditions of water deprivation. Since AVP has a low half-life in the plasma, the C-terminal fragment of AVP-precursor (copeptin) was used to estimate the AVP levels. High copeptin levels increase the risk for the development of diabetes mellit...

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Autores principales: Vintilă, M, Gheorghiu, ML, Caragheorgheopol, A, Baculescu, N, Lichiardopol, C, Badiu, C, Coculescu, M, Grigorescu, F, Poiană, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141393/
https://www.ncbi.nlm.nih.gov/pubmed/27928437
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author Vintilă, M
Gheorghiu, ML
Caragheorgheopol, A
Baculescu, N
Lichiardopol, C
Badiu, C
Coculescu, M
Grigorescu, F
Poiană, C
author_facet Vintilă, M
Gheorghiu, ML
Caragheorgheopol, A
Baculescu, N
Lichiardopol, C
Badiu, C
Coculescu, M
Grigorescu, F
Poiană, C
author_sort Vintilă, M
collection PubMed
description Rationale: Arginine vasopressin (AVP) is secreted under conditions of water deprivation. Since AVP has a low half-life in the plasma, the C-terminal fragment of AVP-precursor (copeptin) was used to estimate the AVP levels. High copeptin levels increase the risk for the development of diabetes mellitus. Aim: This study was aimed to measure copeptin levels in the metabolic syndrome (MetS) in Romanians using a competitive enzyme immunoassay. Methods and results: Patients prone to present MetS (n = 63) were compared to controls (n = 42). In the MetS group, the syndrome was confirmed in 93.6%. Affected patients displayed 85.7% obesity and insulin resistance (HOMAIR of 4.9 ± 0.4 versus 1.1 ± 0.8 in controls). Low HDL-cholesterol was less represented (47.5%). Copeptin levels were 0.6 ± 0.0 in MetS versus 0.42 ± 0.0 ng/ mL in controls (P < 0.004). Higher copeptin (0.79 to 1.83 ng/ mL) was associated with MetS, P < 0.0018, OR 20, 95%CI [3.03 – 131.7]. In ANOVA, high copeptin was equally explained by MetS or obesity (P < 0.05,α = 3.8). The best correlation was found with high triglyceride levels (P < 0.013,α = 6.3) while the correlation with HOMAIR remained not significant. Discussion: These data indicated a concordant correlation between increased copeptin and MetS or its components. In the light of epidemiological data, indicating that more than 50% of the European population has a lower daily water intake and a fraction of 25% displaying high copeptin, our data further sustained that copeptin may be a good biomarker for MetS and/ or obesity, which should be further investigated with other members of the osmoregulation pathway at both pathogenesis and genetic levels.
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spelling pubmed-51413932016-12-07 Increased copeptin levels in metabolic syndrome from a Romanian population Vintilă, M Gheorghiu, ML Caragheorgheopol, A Baculescu, N Lichiardopol, C Badiu, C Coculescu, M Grigorescu, F Poiană, C J Med Life Original Articles Rationale: Arginine vasopressin (AVP) is secreted under conditions of water deprivation. Since AVP has a low half-life in the plasma, the C-terminal fragment of AVP-precursor (copeptin) was used to estimate the AVP levels. High copeptin levels increase the risk for the development of diabetes mellitus. Aim: This study was aimed to measure copeptin levels in the metabolic syndrome (MetS) in Romanians using a competitive enzyme immunoassay. Methods and results: Patients prone to present MetS (n = 63) were compared to controls (n = 42). In the MetS group, the syndrome was confirmed in 93.6%. Affected patients displayed 85.7% obesity and insulin resistance (HOMAIR of 4.9 ± 0.4 versus 1.1 ± 0.8 in controls). Low HDL-cholesterol was less represented (47.5%). Copeptin levels were 0.6 ± 0.0 in MetS versus 0.42 ± 0.0 ng/ mL in controls (P < 0.004). Higher copeptin (0.79 to 1.83 ng/ mL) was associated with MetS, P < 0.0018, OR 20, 95%CI [3.03 – 131.7]. In ANOVA, high copeptin was equally explained by MetS or obesity (P < 0.05,α = 3.8). The best correlation was found with high triglyceride levels (P < 0.013,α = 6.3) while the correlation with HOMAIR remained not significant. Discussion: These data indicated a concordant correlation between increased copeptin and MetS or its components. In the light of epidemiological data, indicating that more than 50% of the European population has a lower daily water intake and a fraction of 25% displaying high copeptin, our data further sustained that copeptin may be a good biomarker for MetS and/ or obesity, which should be further investigated with other members of the osmoregulation pathway at both pathogenesis and genetic levels. Carol Davila University Press 2016 /pmc/articles/PMC5141393/ /pubmed/27928437 Text en ©Carol Davila University Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Vintilă, M
Gheorghiu, ML
Caragheorgheopol, A
Baculescu, N
Lichiardopol, C
Badiu, C
Coculescu, M
Grigorescu, F
Poiană, C
Increased copeptin levels in metabolic syndrome from a Romanian population
title Increased copeptin levels in metabolic syndrome from a Romanian population
title_full Increased copeptin levels in metabolic syndrome from a Romanian population
title_fullStr Increased copeptin levels in metabolic syndrome from a Romanian population
title_full_unstemmed Increased copeptin levels in metabolic syndrome from a Romanian population
title_short Increased copeptin levels in metabolic syndrome from a Romanian population
title_sort increased copeptin levels in metabolic syndrome from a romanian population
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141393/
https://www.ncbi.nlm.nih.gov/pubmed/27928437
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