A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia

Introduction. Ibrutinib is commonly used for the treatment of patients with CLL in either first-line or relapsed/refractory settings. Case Presentation. We present the case of a 74-year-old Caucasian man with CLL who presented with penile gangrene upon initiation of ibrutinib treatment. Our case is...

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Autores principales: Skelton IV, William Paul, Akhavan, Neeka N., Taylor, Zachary A., Nguyen, Thu-Cuc, Hassan, Hassan, Townsend, Tabitha N., Pathak, Prajwol, Trikha, Gaurav, Dang, Nam H., Dang, Long H., Ali, Azka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141545/
https://www.ncbi.nlm.nih.gov/pubmed/27999696
http://dx.doi.org/10.1155/2016/6980198
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author Skelton IV, William Paul
Akhavan, Neeka N.
Taylor, Zachary A.
Nguyen, Thu-Cuc
Hassan, Hassan
Townsend, Tabitha N.
Pathak, Prajwol
Trikha, Gaurav
Dang, Nam H.
Dang, Long H.
Ali, Azka
author_facet Skelton IV, William Paul
Akhavan, Neeka N.
Taylor, Zachary A.
Nguyen, Thu-Cuc
Hassan, Hassan
Townsend, Tabitha N.
Pathak, Prajwol
Trikha, Gaurav
Dang, Nam H.
Dang, Long H.
Ali, Azka
author_sort Skelton IV, William Paul
collection PubMed
description Introduction. Ibrutinib is commonly used for the treatment of patients with CLL in either first-line or relapsed/refractory settings. Case Presentation. We present the case of a 74-year-old Caucasian man with CLL who presented with penile gangrene upon initiation of ibrutinib treatment. Our case is the first showing the complication of penile gangrene associated with ibrutinib use. The gangrene was self-limited upon discontinuing ibrutinib. Conclusion. Our finding describes a very rare yet important adverse event associated with ibrutinib use.
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spelling pubmed-51415452016-12-20 A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia Skelton IV, William Paul Akhavan, Neeka N. Taylor, Zachary A. Nguyen, Thu-Cuc Hassan, Hassan Townsend, Tabitha N. Pathak, Prajwol Trikha, Gaurav Dang, Nam H. Dang, Long H. Ali, Azka Case Rep Oncol Med Case Report Introduction. Ibrutinib is commonly used for the treatment of patients with CLL in either first-line or relapsed/refractory settings. Case Presentation. We present the case of a 74-year-old Caucasian man with CLL who presented with penile gangrene upon initiation of ibrutinib treatment. Our case is the first showing the complication of penile gangrene associated with ibrutinib use. The gangrene was self-limited upon discontinuing ibrutinib. Conclusion. Our finding describes a very rare yet important adverse event associated with ibrutinib use. Hindawi Publishing Corporation 2016 2016-11-23 /pmc/articles/PMC5141545/ /pubmed/27999696 http://dx.doi.org/10.1155/2016/6980198 Text en Copyright © 2016 William Paul Skelton IV et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Skelton IV, William Paul
Akhavan, Neeka N.
Taylor, Zachary A.
Nguyen, Thu-Cuc
Hassan, Hassan
Townsend, Tabitha N.
Pathak, Prajwol
Trikha, Gaurav
Dang, Nam H.
Dang, Long H.
Ali, Azka
A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia
title A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia
title_full A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia
title_fullStr A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia
title_full_unstemmed A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia
title_short A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia
title_sort novel case of penile gangrene in a patient treated with ibrutinib for chronic lymphocytic leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141545/
https://www.ncbi.nlm.nih.gov/pubmed/27999696
http://dx.doi.org/10.1155/2016/6980198
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