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Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease

Introduction. Based on anecdotal reports of improved olfaction following aerobic exercise, the aim of this study was to evaluate the effects of an 8-week aerobic exercise program on olfaction function in individuals with Parkinson's disease (PD). Methods. Thirty-eight participants with idiopath...

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Autores principales: Rosenfeldt, Anson B., Dey, Tanujit, Alberts, Jay L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141565/
https://www.ncbi.nlm.nih.gov/pubmed/27999706
http://dx.doi.org/10.1155/2016/9725089
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author Rosenfeldt, Anson B.
Dey, Tanujit
Alberts, Jay L.
author_facet Rosenfeldt, Anson B.
Dey, Tanujit
Alberts, Jay L.
author_sort Rosenfeldt, Anson B.
collection PubMed
description Introduction. Based on anecdotal reports of improved olfaction following aerobic exercise, the aim of this study was to evaluate the effects of an 8-week aerobic exercise program on olfaction function in individuals with Parkinson's disease (PD). Methods. Thirty-eight participants with idiopathic PD were randomized to either an aerobic exercise group (n = 23) or a nonexercise control group (n = 15). The aerobic exercise group completed a 60-minute cycling session three times per week for eight weeks while the nonexercise control group received no intervention. All participants completed the University of Pennsylvania Smell Identification Test (UPSIT) at baseline, end of treatment, and a four-week follow up. Results. Change in UPSIT scores between the exercise and nonexercise groups from baseline to EOT (p = 0.01) and from baseline to EOT+4 (p = 0.02) favored the aerobic exercise group. Individuals in the nonexercise group had worsening olfaction function over time, while the exercise group was spared from decline. Discussion. The difference in UPSIT scores suggested that aerobic exercise may be altering central nervous system pathways that regulate the physiologic or cognitive processes controlling olfaction in individuals with PD. While these results provide promising preliminary evidence that exercise may modify the disease process, further systematic evaluation is necessary.
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spelling pubmed-51415652016-12-20 Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease Rosenfeldt, Anson B. Dey, Tanujit Alberts, Jay L. Parkinsons Dis Research Article Introduction. Based on anecdotal reports of improved olfaction following aerobic exercise, the aim of this study was to evaluate the effects of an 8-week aerobic exercise program on olfaction function in individuals with Parkinson's disease (PD). Methods. Thirty-eight participants with idiopathic PD were randomized to either an aerobic exercise group (n = 23) or a nonexercise control group (n = 15). The aerobic exercise group completed a 60-minute cycling session three times per week for eight weeks while the nonexercise control group received no intervention. All participants completed the University of Pennsylvania Smell Identification Test (UPSIT) at baseline, end of treatment, and a four-week follow up. Results. Change in UPSIT scores between the exercise and nonexercise groups from baseline to EOT (p = 0.01) and from baseline to EOT+4 (p = 0.02) favored the aerobic exercise group. Individuals in the nonexercise group had worsening olfaction function over time, while the exercise group was spared from decline. Discussion. The difference in UPSIT scores suggested that aerobic exercise may be altering central nervous system pathways that regulate the physiologic or cognitive processes controlling olfaction in individuals with PD. While these results provide promising preliminary evidence that exercise may modify the disease process, further systematic evaluation is necessary. Hindawi Publishing Corporation 2016 2016-11-23 /pmc/articles/PMC5141565/ /pubmed/27999706 http://dx.doi.org/10.1155/2016/9725089 Text en Copyright © 2016 Anson B. Rosenfeldt et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rosenfeldt, Anson B.
Dey, Tanujit
Alberts, Jay L.
Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease
title Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease
title_full Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease
title_fullStr Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease
title_full_unstemmed Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease
title_short Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease
title_sort aerobic exercise preserves olfaction function in individuals with parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141565/
https://www.ncbi.nlm.nih.gov/pubmed/27999706
http://dx.doi.org/10.1155/2016/9725089
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