The biological effects and clinical implications of BRCA mutations: where do we go from here?

BRCA1 and BRCA2 are tumour-suppressor genes encoding proteins that are essential for the repair of DNA double-strand breaks by homologous recombination (HR). Cells that lack either BRCA1 or BRCA2 repair these lesions by alternative, more error-prone mechanisms. Individuals carrying germline pathogen...

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Detalles Bibliográficos
Autor principal: Stoppa-Lyonnet, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141575/
https://www.ncbi.nlm.nih.gov/pubmed/27514841
http://dx.doi.org/10.1038/ejhg.2016.93

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141575/
https://www.ncbi.nlm.nih.gov/pubmed/27514841
http://dx.doi.org/10.1038/ejhg.2016.93

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