Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains

During the 2013–2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals pr...

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Autores principales: Petrie, Joshua G., Parkhouse, Kaela, Ohmit, Suzanne E., Malosh, Ryan E., Monto, Arnold S., Hensley, Scott E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142093/
https://www.ncbi.nlm.nih.gov/pubmed/27923954
http://dx.doi.org/10.1093/infdis/jiw479
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author Petrie, Joshua G.
Parkhouse, Kaela
Ohmit, Suzanne E.
Malosh, Ryan E.
Monto, Arnold S.
Hensley, Scott E.
author_facet Petrie, Joshua G.
Parkhouse, Kaela
Ohmit, Suzanne E.
Malosh, Ryan E.
Monto, Arnold S.
Hensley, Scott E.
author_sort Petrie, Joshua G.
collection PubMed
description During the 2013–2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013–2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 strain possessing the K166Q mutation but not with HAI titers against the current A(H1N1)pdm09 vaccine strain, which lacks this mutation. These data indicate that contemporary A(H1N1)pdm09 strains are antigenically distinct from the current A(H1N1)pdm09 vaccine strain.
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spelling pubmed-51420932017-12-15 Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains Petrie, Joshua G. Parkhouse, Kaela Ohmit, Suzanne E. Malosh, Ryan E. Monto, Arnold S. Hensley, Scott E. J Infect Dis Major Articles and Brief Reports During the 2013–2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013–2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 strain possessing the K166Q mutation but not with HAI titers against the current A(H1N1)pdm09 vaccine strain, which lacks this mutation. These data indicate that contemporary A(H1N1)pdm09 strains are antigenically distinct from the current A(H1N1)pdm09 vaccine strain. Oxford University Press 2016-12-15 2016-10-07 /pmc/articles/PMC5142093/ /pubmed/27923954 http://dx.doi.org/10.1093/infdis/jiw479 Text en © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Major Articles and Brief Reports
Petrie, Joshua G.
Parkhouse, Kaela
Ohmit, Suzanne E.
Malosh, Ryan E.
Monto, Arnold S.
Hensley, Scott E.
Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains
title Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains
title_full Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains
title_fullStr Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains
title_full_unstemmed Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains
title_short Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains
title_sort antibodies against the current influenza a(h1n1) vaccine strain do not protect some individuals from infection with contemporary circulating influenza a(h1n1) virus strains
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142093/
https://www.ncbi.nlm.nih.gov/pubmed/27923954
http://dx.doi.org/10.1093/infdis/jiw479
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