Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei

BACKGROUND: Due to the ability of the 8-aminoquinolines (8AQs) to kill different stages of the malaria parasite, primaquine (PQ) and tafenoquine (TQ) are vital for causal prophylaxis and the eradication of erythrocytic Plasmodium sp. parasites. Recognizing the potential role of cytochrome (CYP) 450...

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Detalles Bibliográficos
Autores principales: Milner, Erin E., Berman, Jonathan, Caridha, Diana, Dickson, Samuel P., Hickman, Mark, Lee, Patricia J., Marcsisin, Sean R., Read, Lisa T., Roncal, Norma, Vesely, Brian A., Xie, Lisa H., Zhang, Jing, Zhang, Ping, Li, Qigui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142148/
https://www.ncbi.nlm.nih.gov/pubmed/27923405
http://dx.doi.org/10.1186/s12936-016-1632-8

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