The paradox role of caspase cascade in ionizing radiation therapy

Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resulted in apoptosis in cancer cells, it also stimulates tumor cell re-population that leads to...

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Detalles Bibliográficos
Autores principales: Rahmanian, Najmeh, Hosseinimehr, Seyed Jalal, Khalaj, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142153/
https://www.ncbi.nlm.nih.gov/pubmed/27923354
http://dx.doi.org/10.1186/s12929-016-0306-8
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author Rahmanian, Najmeh
Hosseinimehr, Seyed Jalal
Khalaj, Ali
author_facet Rahmanian, Najmeh
Hosseinimehr, Seyed Jalal
Khalaj, Ali
author_sort Rahmanian, Najmeh
collection PubMed
description Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resulted in apoptosis in cancer cells, it also stimulates tumor cell re-population that leads to reduce the effectiveness of the radiation therapy. This review describes the mechanisms for paradox role of caspase cascade in cancer therapy and discusses the logical and practical strategies for improvement the therapeutic index of radiotherapy through enhancement of radiosensitivity and decreasing the rate of tumor recurrence.
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spelling pubmed-51421532016-12-15 The paradox role of caspase cascade in ionizing radiation therapy Rahmanian, Najmeh Hosseinimehr, Seyed Jalal Khalaj, Ali J Biomed Sci Review Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resulted in apoptosis in cancer cells, it also stimulates tumor cell re-population that leads to reduce the effectiveness of the radiation therapy. This review describes the mechanisms for paradox role of caspase cascade in cancer therapy and discusses the logical and practical strategies for improvement the therapeutic index of radiotherapy through enhancement of radiosensitivity and decreasing the rate of tumor recurrence. BioMed Central 2016-12-07 /pmc/articles/PMC5142153/ /pubmed/27923354 http://dx.doi.org/10.1186/s12929-016-0306-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Rahmanian, Najmeh
Hosseinimehr, Seyed Jalal
Khalaj, Ali
The paradox role of caspase cascade in ionizing radiation therapy
title The paradox role of caspase cascade in ionizing radiation therapy
title_full The paradox role of caspase cascade in ionizing radiation therapy
title_fullStr The paradox role of caspase cascade in ionizing radiation therapy
title_full_unstemmed The paradox role of caspase cascade in ionizing radiation therapy
title_short The paradox role of caspase cascade in ionizing radiation therapy
title_sort paradox role of caspase cascade in ionizing radiation therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142153/
https://www.ncbi.nlm.nih.gov/pubmed/27923354
http://dx.doi.org/10.1186/s12929-016-0306-8
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