Cargando…

Recent developments in emerging therapeutic targets of osteoarthritis

PURPOSE OF REVIEW: Despite the tremendous individual suffering and socioeconomic burden caused by osteoarthritis, there are currently no effective disease-modifying treatment options. This is in part because of our incomplete understanding of osteoarthritis disease mechanism. This review summarizes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Margaret Man-Ger, Beier, Frank, Pest, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams And Wilkins 2017
Materias:	OSTEOARTHRITIS: Edited by Mukundan Attur
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142371/ https://www.ncbi.nlm.nih.gov/pubmed/27906752 http://dx.doi.org/10.1097/BOR.0000000000000351

Ejemplares similares

Ribosome dysfunction in osteoarthritis
por: van den Akker, Guus G.H., et al.
Publicado: (2022)

The gut microbiome-joint connection: implications in osteoarthritis
por: Favazzo, Lacey J., et al.
Publicado: (2020)

Insights into the molecular landscape of osteoarthritis in human tissues
por: Katsoula, Georgia, et al.
Publicado: (2022)

Blood and urine biomarkers in osteoarthritis – an update on cartilage associated type II collagen and aggrecan markers
por: Bay-Jensen, Anne C., et al.
Publicado: (2022)

Development of classification criteria for hand osteoarthritis: comparative analyses of persons with and without hand osteoarthritis
por: Haugen, Ida K, et al.
Publicado: (2020)

Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis
por: Berthelot, Jean-Marie, et al.
Publicado: (2019)

Magnetic Resonance Imaging–Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis
por: Macri, Erin M., et al.
Publicado: (2022)

Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain
por: Huang, Junting, et al.
Publicado: (2017)

Towards secondary prevention of early knee osteoarthritis
por: Mahmoudian, Armaghan, et al.
Publicado: (2018)

Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study
por: Zhu, Yanqiu, et al.
Publicado: (2023)

Metformin limits osteoarthritis development and progression through activation of AMPK signalling
por: Li, Jun, et al.
Publicado: (2020)

Insights into osteoarthritis development from single-cell RNA sequencing of subchondral bone
por: Shen, Ping, et al.
Publicado: (2022)

Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study
por: Wei, Jie, et al.
Publicado: (2021)

Machine-learning, MRI bone shape and important clinical outcomes in osteoarthritis: data from the Osteoarthritis Initiative
por: Bowes, Michael A., et al.
Publicado: (2021)

Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis
por: von Loga, Isabell S, et al.
Publicado: (2019)

Development of radiographic classification criteria for hand osteoarthritis: a methodological report (Phase 2)
por: Haugen, Ida K, et al.
Publicado: (2022)

CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene
por: Shen, Shuying, et al.
Publicado: (2019)

Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative
por: Camacho-Encina, María, et al.
Publicado: (2019)

Economic Evaluation of the Dr. Bart Application in Individuals With Knee and/or Hip Osteoarthritis
por: Pelle, Tim, et al.
Publicado: (2022)

Average symptom trajectories following incident radiographic knee osteoarthritis: data from the Osteoarthritis Initiative
por: Whittle, Rebecca, et al.
Publicado: (2016)

Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis
por: Rushton, Michael D, et al.
Publicado: (2014)

Structural Associations of Symptomatic Knee Osteoarthritis
por: Stoppiello, Laura A, et al.
Publicado: (2014)

Obesity, osteoarthritis and genetic risk: The rs182052 polymorphism in the ADIPOQ gene is potentially associated with risk of knee osteoarthritis
por: Jiang, L., et al.
Publicado: (2018)

Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritis
por: Hu, Yan, et al.
Publicado: (2022)

Non-surgical management of knee osteoarthritis: where are we now and where do we need to go?
por: Buttgereit, Frank, et al.
Publicado: (2015)

Critical role for arginase II in osteoarthritis pathogenesis
por: Choi, Wan-Su, et al.
Publicado: (2019)

Diabetes mellitus is not a risk factor for osteoarthritis
por: Khor, Andrew, et al.
Publicado: (2020)

Increased risk of osteoarthritis in patients with atopic disease
por: Baker, Matthew C, et al.
Publicado: (2023)

Mechanical stress contributes to osteoarthritis development through the activation of transforming growth factor beta 1 (TGF-β1)
por: Zhang, R-K., et al.
Publicado: (2018)

Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene
por: Boer, Cindy Germaine, et al.
Publicado: (2021)

Pain in hand osteoarthritis is associated with crystals in the synovial fluid: a cross-sectional study of people with hand osteoarthritis undergoing surgery
por: Døssing, Anna, et al.
Publicado: (2023)

Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant
por: Shepherd, Colin, et al.
Publicado: (2018)

TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis
por: Jeon, Jimin, et al.
Publicado: (2020)

The effects of different antihypertensive drugs on pain and joint space width of knee osteoarthritis – A comparative study with data from Osteoarthritis Initiative
por: Li, Mingyang, et al.
Publicado: (2021)

Willingness to Undergo Joint Surgery Following a First‐Line Intervention for Osteoarthritis: Data From the Better Management of People With Osteoarthritis Register
por: Dell’Isola, Andrea, et al.
Publicado: (2021)

Ultrasound-detected osteophytes predict the development of radiographic and clinical features of hand osteoarthritis in the same finger joints 5 years later
por: Mathiessen, Alexander, et al.
Publicado: (2017)

Men and Women's Occupational Activities and the Risk of Developing Osteoarthritis of the Knee, Hip, or Hands: A Systematic Review and Recommendations for Future Research
por: Gignac, Monique A. M., et al.
Publicado: (2020)

Translation of clinical problems in osteoarthritis into pathophysiological research goals
por: van der Kraan, Peter M, et al.
Publicado: (2016)

Genomic Risk Score for Advanced Osteoarthritis in Older Adults
por: Lacaze, Paul, et al.
Publicado: (2022)

Preliminary validation of the Knee Inflammation MRI Scoring System (KIMRISS) for grading bone marrow lesions in osteoarthritis of the knee: data from the Osteoarthritis Initiative
por: Jaremko, Jacob L, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g84nrg77u1p4oum32g5oenj0cs