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Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells

BACKGROUND: Neuroendocrine cells (NECs) reside adjacent to colonic stem cells (SCs) in the crypt stem cell (SC) niche, but how NECs are involved in regulation of SCs is unclear. We investigated NECs expressing somatostatin (SST) and somatostatin receptor type 1 (SSTR1) because SST inhibits intestina...

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Detalles Bibliográficos
Autores principales:	Modarai, Shirin R., Opdenaker, Lynn M., Viswanathan, Vignesh, Fields, Jeremy Z., Boman, Bruce M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142402/ https://www.ncbi.nlm.nih.gov/pubmed/27927191 http://dx.doi.org/10.1186/s12885-016-2969-7

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