Cargando…

Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells

BACKGROUND: Neuroendocrine cells (NECs) reside adjacent to colonic stem cells (SCs) in the crypt stem cell (SC) niche, but how NECs are involved in regulation of SCs is unclear. We investigated NECs expressing somatostatin (SST) and somatostatin receptor type 1 (SSTR1) because SST inhibits intestina...

Descripción completa

Detalles Bibliográficos
Autores principales:	Modarai, Shirin R., Opdenaker, Lynn M., Viswanathan, Vignesh, Fields, Jeremy Z., Boman, Bruce M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142402/ https://www.ncbi.nlm.nih.gov/pubmed/27927191 http://dx.doi.org/10.1186/s12885-016-2969-7

Ejemplares similares

MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies miRNA92a as a Regulator of the LRIG1 Stem Cell Gene
por: Viswanathan, Vignesh, et al.
Publicado: (2020)

The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells
por: Modarai, Shirin R., et al.
Publicado: (2018)

The Proportion of ALDEFLUOR-Positive Cancer Stem Cells Changes with Cell Culture Density Due to the Expression of Different ALDH Isoforms
por: Opdenaker, Lynn M., et al.
Publicado: (2015)

APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development
por: Zhang, Tao, et al.
Publicado: (2020)

Differential miRNA Expression Contributes to Emergence of Multiple Cancer Stem Cell Subpopulations in Human Colorectal Cancer
por: Stark, Victoria A., et al.
Publicado: (2023)

Increased Musashi-2 and Decreased NUMB Protein Levels Observed in Human Colorectal Cancer are reverted to Normal Levels by ATRA-Induced Cell Differentiation
por: Opdenaker, Lynn M, et al.
Publicado: (2018)

The v8-10 variant isoform of CD44 is selectively expressed in the normal human colonic stem cell niche and frequently is overexpressed in colon carcinomas during tumor development
por: Boman, Bruce M., et al.
Publicado: (2023)

mRNA expression of somatostatin receptor subtypes SSTR-2, SSTR-3, and SSTR-5 and its significance in pancreatic cancer
por: Shahbaz, Muhammad, et al.
Publicado: (2015)

Expression of Somatostatin Receptor Subtypes (SSTR-1–SSTR-5) in Pediatric Hematological and Oncological Disorders
por: Harda, Kristof, et al.
Publicado: (2020)

Clinical Significance of Somatostatin Receptor (SSTR) 2 in Meningioma
por: Wu, Wei, et al.
Publicado: (2020)

Clinical Importance of Somatostatin Receptor 2 (SSTR2) and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma)
por: Yu, Benxia, et al.
Publicado: (2017)

Coexpression of human somatostatin receptor-2 (SSTR2) and SSTR3 modulates antiproliferative signaling and apoptosis
por: War, Sajad A, et al.
Publicado: (2012)

Retracted: Clinical Importance of Somatostatin Receptor 2 (SSTR2) and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma)
por: Song, Hao, et al.
Publicado: (2018)

Beta cell primary cilia mediate somatostatin responsiveness via SSTR3
por: Adamson, Samantha E., et al.
Publicado: (2023)

Somatostatin receptors (SSTR1-5) on inhibitory interneurons in the barrel cortex
por: Lukomska, Agnieszka, et al.
Publicado: (2019)

Molecular Imaging of Vulnerable Coronary Plaque with Radiolabeled Somatostatin Receptors (SSTR)
por: Anzola, Luz Kelly, et al.
Publicado: (2021)

FRI623 Beta Cell Primary Cilia Mediate Somatostatin Responsiveness Via SSTR3
por: Elizabeth Adamson, Samantha, et al.
Publicado: (2023)

Precise and error-prone CRISPR-directed gene editing activity in human CD34+ cells varies widely among patient samples
por: Modarai, Shirin R., et al.
Publicado: (2020)

An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development
por: Boman, Bruce M., et al.
Publicado: (2013)

Novel Discovery of the Somatostatin Receptor (SSTR2) in Pleomorphic Adenomas via Immunohistochemical Analysis of Tumors of the Salivary Glands
por: Johnson, Felix, et al.
Publicado: (2023)

Expression of Somatostatin Receptor (SSTR) Subtypes (SSTR-1, 2A, 3, 4 and 5) in Neuroendocrine Tumors Using Real-time RT-PCR Method and Immunohistochemistry
por: Mizutani, Gou, et al.
Publicado: (2012)

Role of HOX Genes in Stem Cell Differentiation and Cancer
por: Bhatlekar, Seema, et al.
Publicado: (2018)

A Cyanine‐Bridged Somatostatin Hybrid Probe for Multimodal SSTR2 Imaging in Vitro and in Vivo: Synthesis and Evaluation
por: Heing‐Becker, Isabelle, et al.
Publicado: (2021)

Synthesis and preliminary evaluation of octreotate conjugates of bioactive synthetic amatoxins for targeting somatostatin receptor (sstr2) expressing cells
por: Pryyma, Alla, et al.
Publicado: (2021)

Identification of Somatostatin Receptor Subtype 1 (SSTR1) Gene Polymorphism and Their Association with Growth Traits in Hulun Buir Sheep
por: Li, Xue, et al.
Publicado: (2021)

Somatostatin Receptor SSTR-2a Expression Is a Stronger Predictor for Survival Than Ki-67 in Pancreatic Neuroendocrine Tumors
por: Mehta, Shreya, et al.
Publicado: (2015)

The effect of strength and endurance training on SSTR2 and SSTR5 in patients with colorectal cancer
por: Zanjani, Farhad Safari, et al.
Publicado: (2019)

The Role of miRNAs, miRNA Clusters, and isomiRs in Development of Cancer Stem Cell Populations in Colorectal Cancer
por: Stark, Victoria A., et al.
Publicado: (2021)

Molecular-Level Understanding of the Somatostatin Receptor 1 (SSTR1)–Ligand Binding: A Structural Biology Study Based on Computational Methods
por: Nagarajan, Santhosh Kumar, et al.
Publicado: (2020)

Comparing the use of radiolabeled SSTR agonists and an SSTR antagonist in breast cancer: does the model choice influence the outcome?
por: Dalm, Simone U., et al.
Publicado: (2017)

Epidermal stem cell diversity and quiescence
por: Watt, Fiona M, et al.
Publicado: (2009)

Validation of the SSTR-RADS 1.0 for the structured interpretation of SSTR-PET/CT and treatment planning in neuroendocrine tumor (NET) patients
por: Grawe, Freba, et al.
Publicado: (2023)

Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression
por: Cariaga-Martinez, Ariel Ernesto, et al.
Publicado: (2009)

lncRNA SSTR5-AS1 Predicts Poor Prognosis and Contributes to the Progression of Esophageal Cancer
por: Hu, Yuhao, et al.
Publicado: (2023)

Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma, but does not involve mutations in the somatostatin receptor 2 (SSTR2) gene at 17q24
por: Abel, F, et al.
Publicado: (1999)

Expressions of Somatostatin Receptor Subtypes (SSTR-1, 2, 3, 4 and 5) in Neuroblastic Tumors; Special Reference to Clinicopathological Correlations with International Neuroblastoma Pathology Classification and Outcomes
por: Watanabe, Noriko, et al.
Publicado: (2014)

Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence
por: Cho, Inchul J., et al.
Publicado: (2019)

Molecular simulations of SSTR2 dynamics and interaction with ligands
por: Gervasoni, Silvia, et al.
Publicado: (2023)

Sterol Metabolism Differentially Contributes to Maintenance and Exit of Quiescence
por: Peselj, Carlotta, et al.
Publicado: (2022)

The aged niche disrupts muscle stem cell quiescence
por: Chakkalakal, Joe V., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_b7ld1spn991c1lmkbcdr8monfv