Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML

Interleukin-12 (IL-12) is a potent cytokine that may be harnessed to treat cancer. To date, nearly 100 IL-12-based clinical trials have been initiated worldwide. Yet systemic administration of IL-12 is toxic. Different strategies are being developed to reduce such toxicities by restricting IL-12 dis...

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Detalles Bibliográficos
Autores principales: Huang, Ju, Liu, Yuanfeng, Au, Bryan C, Barber, Dwayne L, Arruda, Andrea, Schambach, Axel, Rothe, Michael, Minden, Mark D, Paige, Christopher J, Medin, Jeffrey A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142463/
https://www.ncbi.nlm.nih.gov/pubmed/27933304
http://dx.doi.org/10.1038/mtm.2016.74

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