Association of Serum Omentin-1 Concentrations with the Presence of Atrial Fibrillation

BACKGROUND: Omentin-1 is one of the adipokines associated with obesity, diabetes, and coronary heart disease development. We determined to investigate whether serum omentin-1 concentrations were correlated with the presence of atrial fibrillation (AF). MATERIAL/METHODS: Serum omentin-1 concentration...

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Detalles Bibliográficos
Autores principales: Tao, Sha, Huang, Yu-Qing, Cai, An-Ping, Huang, Cheng, Zhang, Ying, Tang, Song-Tao, Yu, Xue-Ju, Zhou, Dan, Tan, Ning, Feng, Ying-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142586/
https://www.ncbi.nlm.nih.gov/pubmed/27915353
http://dx.doi.org/10.12659/MSM.898202
Descripción
Sumario:BACKGROUND: Omentin-1 is one of the adipokines associated with obesity, diabetes, and coronary heart disease development. We determined to investigate whether serum omentin-1 concentrations were correlated with the presence of atrial fibrillation (AF). MATERIAL/METHODS: Serum omentin-1 concentrations were examined in a cross-sectional population that included 220 patients with AF (70 with paroxysmal AF, 78 with persistent AF, and 72 with permanent AF) and 115 healthy controls. RESULTS: Reduced serum omentin-1 concentrations were found in AF patients compared to the controls. In addition, patients with permanent AF had lower serum omentin-1 concentrations compared to patients with persistent AF and patients with paroxysmal AF. Significantly decreased serum omentin-1 concentrations were observed in persistent AF patients compared to paroxysmal AF patients. Spearman correlation analysis suggested that serum omentin-1 concentrations were negatively correlated with left atrial diameter in AF patients. CONCLUSIONS: Serum omentin-1 concentrations were correlated with the presence of AF and atrial remolding.

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