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A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein

Misfolded proteins in transgenic models of conformational diseases interfere with proteostasis machinery and compromise the function of many structurally and functionally unrelated metastable proteins. This collateral damage to cellular proteins has been termed 'bystander' mechanism. How a...

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Detalles Bibliográficos
Autores principales:	Klabonski, Lauren, Zha, Ji, Senthilkumar, Lakshana, Gidalevitz, Tali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142776/ https://www.ncbi.nlm.nih.gov/pubmed/27926939 http://dx.doi.org/10.1371/journal.pgen.1006450

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