Structure of protein O-mannose kinase reveals a unique active site architecture

The ‘pseudokinase’ SgK196 is a protein O-mannose kinase (POMK) that catalyzes an essential phosphorylation step during biosynthesis of the laminin-binding glycan on α-dystroglycan. However, the catalytic mechanism underlying this activity remains elusive. Here we present the crystal structure of Dan...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Qinyu, Venzke, David, Walimbe, Ameya S, Anderson, Mary E, Fu, Qiuyu, Kinch, Lisa N, Wang, Wei, Chen, Xing, Grishin, Nick V, Huang, Niu, Yu, Liping, Dixon, Jack E, Campbell, Kevin P, Xiao, Junyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142810/
https://www.ncbi.nlm.nih.gov/pubmed/27879205
http://dx.doi.org/10.7554/eLife.22238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142810/
https://www.ncbi.nlm.nih.gov/pubmed/27879205
http://dx.doi.org/10.7554/eLife.22238

Ejemplares similares