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Structure of protein O-mannose kinase reveals a unique active site architecture

The ‘pseudokinase’ SgK196 is a protein O-mannose kinase (POMK) that catalyzes an essential phosphorylation step during biosynthesis of the laminin-binding glycan on α-dystroglycan. However, the catalytic mechanism underlying this activity remains elusive. Here we present the crystal structure of Dan...

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Detalles Bibliográficos
Autores principales:	Zhu, Qinyu, Venzke, David, Walimbe, Ameya S, Anderson, Mary E, Fu, Qiuyu, Kinch, Lisa N, Wang, Wei, Chen, Xing, Grishin, Nick V, Huang, Niu, Yu, Liping, Dixon, Jack E, Campbell, Kevin P, Xiao, Junyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142810/ https://www.ncbi.nlm.nih.gov/pubmed/27879205 http://dx.doi.org/10.7554/eLife.22238

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