Small Molecule Inhibition of cAMP Response Element Binding Protein in Human Acute Myeloid Leukemia Cells

The transcription factor CREB (cAMP Response Element Binding Protein) is overexpressed in the majority of acute myeloid leukemia (AML) patients, and this is associated with a worse prognosis. Previous work revealed that CREB overexpression augmented AML cell growth, while CREB knockdown disrupted ke...

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Detalles Bibliográficos
Autores principales: Mitton, Bryan, Chae, Hee-Don, Hsu, Katie, Dutta, Ritika, Aldana-Masangkay, Grace, Ferrari, Roberto, Davis, Kara, Tiu, Bruce C., Kaul, Arya, Lacayo, Norman, Dahl, Gary, Xie, Fuchun, Li, Bingbing X., Breese, Marcus R., Landaw, Elliot M., Nolan, Garry, Pellegrini, Matteo, Romanov, Sergei, Xiao, Xiangshu, Sakamoto, Kathleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143163/
https://www.ncbi.nlm.nih.gov/pubmed/27211267
http://dx.doi.org/10.1038/leu.2016.139

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