Cargando…

Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis

BC200 is a long non-coding RNA (lncRNA) that has been implicated in the regulation of protein synthesis, yet whether dysregulation of BC200 contributes to the pathogenesis of human diseases remains elusive. In this study, we show that BC200 is upregulated in breast cancer; among breast tumor specime...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, R, Gupta, S C, Peng, W-X, Zhou, N, Pochampally, R, Atfi, A, Watabe, K, Lu, Z, Mo, Y-Y
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143396/ https://www.ncbi.nlm.nih.gov/pubmed/27277684 http://dx.doi.org/10.1038/cddis.2016.168

Ejemplares similares

BC200 overexpression contributes to luminal and triple negative breast cancer pathogenesis
por: Barton, Maria, et al.
Publicado: (2019)

Alternative splicing of BCL-X and implications for treating hematological malignancies
por: Chen, Wanling, et al.
Publicado: (2021)

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X
por: Weldon, Carika, et al.
Publicado: (2018)

Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing
por: Stevens, Megan, et al.
Publicado: (2019)

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
por: Paronetto, Maria Paola, et al.
Publicado: (2007)

Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA
por: Le Sénéchal, Ronan, et al.
Publicado: (2023)

Modulation of Bcl-x Alternative Splicing Induces Apoptosis of Human Hepatic Stellate Cells
por: Wu, Lin, et al.
Publicado: (2016)

BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR
por: Aguirre, Clémentine, et al.
Publicado: (2013)

Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF
por: Chen, Zhiqi, et al.
Publicado: (2010)

LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing
por: Chen, Qi Wen, et al.
Publicado: (2023)

Alternative mRNA Splicing in the Pathogenesis of Obesity
por: Wong, Chi-Ming, et al.
Publicado: (2018)

Alternative RNA Splicing in the Pathogenesis of Liver Disease
por: Webster, Nicholas J. G.
Publicado: (2017)

Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway
por: Gupta, Subash C., et al.
Publicado: (2014)

Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA
por: Choi, Namjeong, et al.
Publicado: (2021)

Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism
por: Sun, Qi, et al.
Publicado: (2018)

Correction: Promoter choice influences alternative splicing and determines the balance of isoforms expressed from the Mouse bcl-X gene
por: Pecci, Adali, et al.
Publicado: (2021)

Dysregulation of alternative splicing is associated with the pathogenesis of ulcerative colitis
por: Li, Daowei, et al.
Publicado: (2021)

Splicing: is there an alternative contribution to Parkinson’s disease?
por: La Cognata, Valentina, et al.
Publicado: (2015)

Mesenchymal Stem/Stromal Cells under Stress Increase Osteosarcoma Migration and Apoptosis Resistance via Extracellular Vesicle Mediated Communication
por: Vallabhaneni, Krishna C., et al.
Publicado: (2016)

The Contribution of COL4A5 Splicing Variants to the Pathogenesis of X-Linked Alport Syndrome
por: Yamamura, Tomohiko, et al.
Publicado: (2022)

Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection
por: Bielli, Pamela, et al.
Publicado: (2014)

Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies
Publicado: (1989)

Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation
por: Dou, Zhihui, et al.
Publicado: (2021)

Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing
por: Montes, Marta, et al.
Publicado: (2015)

Biophysical characterisation of the Bcl-x pre-mRNA and binding specificity of the ellipticine derivative GQC-05: Implication for alternative splicing regulation
por: Bhogadia, Mohammed, et al.
Publicado: (2022)

Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer
por: Singh, Ramesh, et al.
Publicado: (2014)

BC200 RNA: An Emerging Therapeutic Target and Diagnostic Marker for Human Cancer
por: Shin, Heegwon, et al.
Publicado: (2018)

Contribution of alternative splicing to breast cancer metastasis
por: Meng, Xiangbing, et al.
Publicado: (2019)

P998: REGULATION OF BCL-X SPLICING BY SRC KINASES INHIBITORS IN MYELOPROLIFERATIVE NEOPLASMS
por: Petiti, J., et al.
Publicado: (2022)

BC200 (BCYRN1) – The shortest, long, non-coding RNA associated with cancer
por: Samson, J., et al.
Publicado: (2018)

Functional analysis of RNA motifs essential for BC200 RNA-mediated translational regulation
por: Jang, Seonghui, et al.
Publicado: (2020)

The Long Non-Coding BC200 Is a Novel Circulating Biomarker of Parathyroid Carcinoma
por: Morotti, Annamaria, et al.
Publicado: (2022)

Alternative Splicing of MoPTEN Is Important for Growth and Pathogenesis in Magnaporthe oryzae
por: Wang, Shaowei, et al.
Publicado: (2021)

Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma
por: Yoshimine, S, et al.
Publicado: (2013)

Cephalometric Characteristics in Skulls with Artificial Deformation in a Pre-Columbian Civilization of the Peruvian Andes (Chavin Civilization 900 B.C. to 200 B.C.)
por: Pérez-Vargas, Fernando, et al.
Publicado: (2021)

BC RNA Mislocalization in the Fragile X Premutation
por: Muslimov, Ilham A., et al.
Publicado: (2018)

U1-independent pre-mRNA splicing contributes to the regulation of alternative splicing
por: Fukumura, Kazuhiro, et al.
Publicado: (2009)

Chimeric peptide nucleic acid compounds modulate splicing of the bcl-x gene in vitro and in vivo
por: Wilusz, Jeremy E., et al.
Publicado: (2005)

Effect of lncRNA-BC200 on proliferation and migration of liver cancer cells in vitro and in vivo
por: Tan, Ni, et al.
Publicado: (2020)

Alternative Splice in Alternative Lice
por: Tovar-Corona, Jaime M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_anob9j5jfh7pboia5q7vom6nah