Identification of a potent small molecule capable of regulating polyploidization, megakaryocyte maturation, and platelet production

BACKGROUND: Megakaryocytic cell maturation involves polyploidization, and megakaryocyte (MK) ploidy correlates with their maturation and platelet production. Retardation of MK maturation is closely associated with poor MK engraftment after cord blood transplantation and neonatal thrombocytopenia. De...

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Detalles Bibliográficos
Autores principales: Huang, Nick, Lou, Mabel, Liu, Hua, Avila, Cecilia, Ma, Yupo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143458/
https://www.ncbi.nlm.nih.gov/pubmed/27927231
http://dx.doi.org/10.1186/s13045-016-0358-y

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