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Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis
AIM: Evaluate the association between phase angle and the development of hepatic encephalopathy in the long-term follow-up of cirrhotic patients. METHODS: This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. Mann-Whitney’s U and χ(2) tests were used...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143753/ https://www.ncbi.nlm.nih.gov/pubmed/28018114 http://dx.doi.org/10.3748/wjg.v22.i45.10064 |
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author | Ruiz-Margáin, Astrid Macías-Rodríguez, Ricardo Ulises Ampuero, Javier Cubero, Francisco Javier Chi-Cervera, Luis Ríos-Torres, Silvia L Duarte-Rojo, Andrés Espinosa-Cuevas, Ángeles Romero-Gómez, Manuel Torre, Aldo |
author_facet | Ruiz-Margáin, Astrid Macías-Rodríguez, Ricardo Ulises Ampuero, Javier Cubero, Francisco Javier Chi-Cervera, Luis Ríos-Torres, Silvia L Duarte-Rojo, Andrés Espinosa-Cuevas, Ángeles Romero-Gómez, Manuel Torre, Aldo |
author_sort | Ruiz-Margáin, Astrid |
collection | PubMed |
description | AIM: Evaluate the association between phase angle and the development of hepatic encephalopathy in the long-term follow-up of cirrhotic patients. METHODS: This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. Mann-Whitney’s U and χ(2) tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy. RESULTS: Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy (18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. Kaplan-Meier curves showed a higher proportion of HE in the group with low phase angle (39%) compared to the normal phase angle group (13%) (P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80 (1.07-3.03)]. CONCLUSION: In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. |
format | Online Article Text |
id | pubmed-5143753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-51437532016-12-23 Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis Ruiz-Margáin, Astrid Macías-Rodríguez, Ricardo Ulises Ampuero, Javier Cubero, Francisco Javier Chi-Cervera, Luis Ríos-Torres, Silvia L Duarte-Rojo, Andrés Espinosa-Cuevas, Ángeles Romero-Gómez, Manuel Torre, Aldo World J Gastroenterol Prospective Study AIM: Evaluate the association between phase angle and the development of hepatic encephalopathy in the long-term follow-up of cirrhotic patients. METHODS: This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. Mann-Whitney’s U and χ(2) tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy. RESULTS: Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy (18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. Kaplan-Meier curves showed a higher proportion of HE in the group with low phase angle (39%) compared to the normal phase angle group (13%) (P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80 (1.07-3.03)]. CONCLUSION: In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. Baishideng Publishing Group Inc 2016-12-07 2016-12-07 /pmc/articles/PMC5143753/ /pubmed/28018114 http://dx.doi.org/10.3748/wjg.v22.i45.10064 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Prospective Study Ruiz-Margáin, Astrid Macías-Rodríguez, Ricardo Ulises Ampuero, Javier Cubero, Francisco Javier Chi-Cervera, Luis Ríos-Torres, Silvia L Duarte-Rojo, Andrés Espinosa-Cuevas, Ángeles Romero-Gómez, Manuel Torre, Aldo Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis |
title | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis |
title_full | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis |
title_fullStr | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis |
title_full_unstemmed | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis |
title_short | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis |
title_sort | low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis |
topic | Prospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143753/ https://www.ncbi.nlm.nih.gov/pubmed/28018114 http://dx.doi.org/10.3748/wjg.v22.i45.10064 |
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