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Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis

AIM: Evaluate the association between phase angle and the development of hepatic encephalopathy in the long-term follow-up of cirrhotic patients. METHODS: This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. Mann-Whitney’s U and χ(2) tests were used...

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Autores principales: Ruiz-Margáin, Astrid, Macías-Rodríguez, Ricardo Ulises, Ampuero, Javier, Cubero, Francisco Javier, Chi-Cervera, Luis, Ríos-Torres, Silvia L, Duarte-Rojo, Andrés, Espinosa-Cuevas, Ángeles, Romero-Gómez, Manuel, Torre, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143753/
https://www.ncbi.nlm.nih.gov/pubmed/28018114
http://dx.doi.org/10.3748/wjg.v22.i45.10064
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author Ruiz-Margáin, Astrid
Macías-Rodríguez, Ricardo Ulises
Ampuero, Javier
Cubero, Francisco Javier
Chi-Cervera, Luis
Ríos-Torres, Silvia L
Duarte-Rojo, Andrés
Espinosa-Cuevas, Ángeles
Romero-Gómez, Manuel
Torre, Aldo
author_facet Ruiz-Margáin, Astrid
Macías-Rodríguez, Ricardo Ulises
Ampuero, Javier
Cubero, Francisco Javier
Chi-Cervera, Luis
Ríos-Torres, Silvia L
Duarte-Rojo, Andrés
Espinosa-Cuevas, Ángeles
Romero-Gómez, Manuel
Torre, Aldo
author_sort Ruiz-Margáin, Astrid
collection PubMed
description AIM: Evaluate the association between phase angle and the development of hepatic encephalopathy in the long-term follow-up of cirrhotic patients. METHODS: This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. Mann-Whitney’s U and χ(2) tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy. RESULTS: Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy (18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. Kaplan-Meier curves showed a higher proportion of HE in the group with low phase angle (39%) compared to the normal phase angle group (13%) (P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80 (1.07-3.03)]. CONCLUSION: In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis.
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spelling pubmed-51437532016-12-23 Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis Ruiz-Margáin, Astrid Macías-Rodríguez, Ricardo Ulises Ampuero, Javier Cubero, Francisco Javier Chi-Cervera, Luis Ríos-Torres, Silvia L Duarte-Rojo, Andrés Espinosa-Cuevas, Ángeles Romero-Gómez, Manuel Torre, Aldo World J Gastroenterol Prospective Study AIM: Evaluate the association between phase angle and the development of hepatic encephalopathy in the long-term follow-up of cirrhotic patients. METHODS: This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. Mann-Whitney’s U and χ(2) tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy. RESULTS: Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy (18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. Kaplan-Meier curves showed a higher proportion of HE in the group with low phase angle (39%) compared to the normal phase angle group (13%) (P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80 (1.07-3.03)]. CONCLUSION: In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. Baishideng Publishing Group Inc 2016-12-07 2016-12-07 /pmc/articles/PMC5143753/ /pubmed/28018114 http://dx.doi.org/10.3748/wjg.v22.i45.10064 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Prospective Study
Ruiz-Margáin, Astrid
Macías-Rodríguez, Ricardo Ulises
Ampuero, Javier
Cubero, Francisco Javier
Chi-Cervera, Luis
Ríos-Torres, Silvia L
Duarte-Rojo, Andrés
Espinosa-Cuevas, Ángeles
Romero-Gómez, Manuel
Torre, Aldo
Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis
title Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis
title_full Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis
title_fullStr Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis
title_full_unstemmed Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis
title_short Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis
title_sort low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis
topic Prospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143753/
https://www.ncbi.nlm.nih.gov/pubmed/28018114
http://dx.doi.org/10.3748/wjg.v22.i45.10064
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