Cargando…

Functional connectivity changes resemble patterns of pTDP-43 pathology in amyotrophic lateral sclerosis

‘Resting-state’ fMRI allows investigation of alterations in functional brain organization that are associated with an underlying pathological process. We determine whether abnormal connectivity in amyotrophic lateral sclerosis (ALS) in a priori-defined intrinsic functional connectivity networks, acc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schulthess, Ines, Gorges, Martin, Müller, Hans-Peter, Lulé, Dorothée, Del Tredici, Kelly, Ludolph, Albert C., Kassubek, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144012/ https://www.ncbi.nlm.nih.gov/pubmed/27929102 http://dx.doi.org/10.1038/srep38391

Ejemplares similares

Eye Movement Deficits Are Consistent with a Staging Model of pTDP-43 Pathology in Amyotrophic Lateral Sclerosis
por: Gorges, Martin, et al.
Publicado: (2015)

Heterogeneity of cortical pTDP-43 inclusion morphologies in amyotrophic lateral sclerosis
por: Tan, Rachel H., et al.
Publicado: (2023)

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis
por: Cykowski, Matthew D., et al.
Publicado: (2018)

Saccadic intrusions in amyotrophic lateral sclerosis (ALS)
por: Becker, Wolfgang, et al.
Publicado: (2019)

Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker
por: Kassubek, Jan, et al.
Publicado: (2018)

Atypical astroglial pTDP‐43 pathology in astroglial predominant tauopathy
por: Gelpi, Ellen, et al.
Publicado: (2021)

Multimodal in vivo staging in amyotrophic lateral sclerosis using artificial intelligence
por: Behler, Anna, et al.
Publicado: (2022)

Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis
por: Braak, Heiko, et al.
Publicado: (2016)

Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis
por: Freischmidt, Axel, et al.
Publicado: (2013)

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
por: Oiwa, Kotaro, et al.
Publicado: (2023)

Corticoefferent pathology distribution in amyotrophic lateral sclerosis: in vivo evidence from a meta-analysis of diffusion tensor imaging data
por: Gorges, Martin, et al.
Publicado: (2018)

TDP-43—The key to understanding amyotrophic lateral sclerosis
por: Xu, Zuoshang, et al.
Publicado: (2014)

The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
por: Suk, Terry R., et al.
Publicado: (2020)

HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis
por: Riemslagh, Frederike W., et al.
Publicado: (2019)

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
por: Prasad, Archana, et al.
Publicado: (2019)

Old age amyotrophic lateral sclerosis and limbic TDP‐43 pathology
por: Murakami, Aya, et al.
Publicado: (2022)

Longitudinal monitoring of amyotrophic lateral sclerosis by diffusion tensor imaging: Power calculations for group studies
por: Behler, Anna, et al.
Publicado: (2022)

TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis
por: Williams, Stephanie M., et al.
Publicado: (2017)

Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis
por: Cykowski, Matthew D., et al.
Publicado: (2017)

TDP‐43 as structure‐based biomarker in amyotrophic lateral sclerosis
por: Beyer, Léon, et al.
Publicado: (2020)

Intracellular Conformation of Amyotrophic Lateral Sclerosis-Causative TDP-43
por: Kitamura, Akira, et al.
Publicado: (2023)

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
por: Ren, Yuting, et al.
Publicado: (2021)

A multivariate Bayesian classification algorithm for cerebral stage prediction by diffusion tensor imaging in amyotrophic lateral sclerosis
por: Behler, Anna, et al.
Publicado: (2022)

TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis
por: Cykowski, Matthew D, et al.
Publicado: (2014)

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations
por: Jeon, Gye Sun, et al.
Publicado: (2018)

Cerebral atrophy in amyotrophic lateral sclerosis parallels the pathological distribution of TDP43
por: Dadar, Mahsa, et al.
Publicado: (2020)

Identical patterns of cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: A tract of interest-based MRI study
por: Müller, Hans-Peter, et al.
Publicado: (2018)

TDP-43 Is Not a Common Cause of Sporadic Amyotrophic Lateral Sclerosis
por: Guerreiro, Rita J., et al.
Publicado: (2008)

TDP-43–specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis
por: Nielsen, Anne Kallehauge, et al.
Publicado: (2020)

TDP-43 and Inflammation: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
por: Bright, Fiona, et al.
Publicado: (2021)

TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis
por: Lépine, Sarah, et al.
Publicado: (2022)

pTDP‐43 aggregates accumulate in non‐central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data
por: Pattle, Samuel B, et al.
Publicado: (2022)

The pathogenic mechanism of TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis
por: Wang, Xinxin, et al.
Publicado: (2023)

Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
por: Rutherford, Nicola J., et al.
Publicado: (2008)

Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains
por: Kametani, Fuyuki, et al.
Publicado: (2016)

Why TDP-43? Why Not? Mechanisms of Metabolic Dysfunction in Amyotrophic Lateral Sclerosis
por: Floare, Mara-Luciana, et al.
Publicado: (2020)

Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations
por: Konopka, Anna, et al.
Publicado: (2020)

A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis
por: Mitra, Joy, et al.
Publicado: (2019)

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis
por: Smethurst, Phillip, et al.
Publicado: (2020)

Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis
por: Fang, Minggang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5vi894et6ocqrra1c3c5kr3uag