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Identification of a CD133−CD55− population functions as a fetal common skeletal progenitor
In this study, we identified a CD105+CD90.1−CD133−CD55− (CD133−CD55−) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133−CD55− common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144148/ https://www.ncbi.nlm.nih.gov/pubmed/27929130 http://dx.doi.org/10.1038/srep38632 |
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author | Weng, Lihong Hu, Xingbin Kumar, Bijender Garcia, Mayra Todorov, Ivan Jung, Xiaoman Marcucci, Guido Forman, Stephen J. Chen, Ching-Cheng |
author_facet | Weng, Lihong Hu, Xingbin Kumar, Bijender Garcia, Mayra Todorov, Ivan Jung, Xiaoman Marcucci, Guido Forman, Stephen J. Chen, Ching-Cheng |
author_sort | Weng, Lihong |
collection | PubMed |
description | In this study, we identified a CD105+CD90.1−CD133−CD55− (CD133−CD55−) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133−CD55− common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133−CD55− common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133−CD55− common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow. |
format | Online Article Text |
id | pubmed-5144148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51441482016-12-16 Identification of a CD133−CD55− population functions as a fetal common skeletal progenitor Weng, Lihong Hu, Xingbin Kumar, Bijender Garcia, Mayra Todorov, Ivan Jung, Xiaoman Marcucci, Guido Forman, Stephen J. Chen, Ching-Cheng Sci Rep Article In this study, we identified a CD105+CD90.1−CD133−CD55− (CD133−CD55−) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133−CD55− common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133−CD55− common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133−CD55− common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow. Nature Publishing Group 2016-12-08 /pmc/articles/PMC5144148/ /pubmed/27929130 http://dx.doi.org/10.1038/srep38632 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Weng, Lihong Hu, Xingbin Kumar, Bijender Garcia, Mayra Todorov, Ivan Jung, Xiaoman Marcucci, Guido Forman, Stephen J. Chen, Ching-Cheng Identification of a CD133−CD55− population functions as a fetal common skeletal progenitor |
title | Identification of a CD133−CD55− population functions as a fetal common skeletal progenitor |
title_full | Identification of a CD133−CD55− population functions as a fetal common skeletal progenitor |
title_fullStr | Identification of a CD133−CD55− population functions as a fetal common skeletal progenitor |
title_full_unstemmed | Identification of a CD133−CD55− population functions as a fetal common skeletal progenitor |
title_short | Identification of a CD133−CD55− population functions as a fetal common skeletal progenitor |
title_sort | identification of a cd133−cd55− population functions as a fetal common skeletal progenitor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144148/ https://www.ncbi.nlm.nih.gov/pubmed/27929130 http://dx.doi.org/10.1038/srep38632 |
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