Clinical correlates of leukoaraiosis: A study of 175 patients

BACKGROUND: In India, the correlates of leukoaraiosis (LA) have not been widely reported. This study was designed to investigate the factors which correlate with LA. MATERIALS AND METHODS: We included patients with LA who consented for the study and graded their severity on the basis of Fazekas scal...

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Detalles Bibliográficos
Autores principales: Wadia, Rustom S., Ghiya, Sandesh K., Singh, Joshita, Sontakke, Santosh M., Bharadwaj, Vishwas, Sonawane, Rahul V., Bade, Yogesh P., Shrikanth, K., Goli, Nikhil, Chauhan, Rohit Singh, Nadkarni, Nilesh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144469/
https://www.ncbi.nlm.nih.gov/pubmed/27994357
http://dx.doi.org/10.4103/0972-2327.194425
Descripción
Sumario:BACKGROUND: In India, the correlates of leukoaraiosis (LA) have not been widely reported. This study was designed to investigate the factors which correlate with LA. MATERIALS AND METHODS: We included patients with LA who consented for the study and graded their severity on the basis of Fazekas scale. We excluded patients with LA who did not consent/cooperate for the study as also patients with other white matter changes which mimic LA. RESULTS: LA is a common and under-rated cause of disability. Presentations include cognitive decline, gait disturbance, dysarthria, bladder/bowel sphincter disturbances, and increased risk of stroke. The comorbidities include hyperhomocysteinemia, hypertension, dyslipidemia, tobacco use, ischemic heart disease, previous stroke, atrial fibrillation, chronic renal failure, and bariatric surgery.

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