Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT(2C) receptor mediated appetite

Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT(2C)R) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Prader-Willi Syndrome (PWS), a multigenic disorder characterised by hyperphagia and obesi...

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Detalles Bibliográficos
Autores principales: Garfield, Alastair S., Davies, Jennifer R., Burke, Luke K., Furby, Hannah V., Wilkinson, Lawrence S., Heisler, Lora K., Isles, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144496/
https://www.ncbi.nlm.nih.gov/pubmed/27931246
http://dx.doi.org/10.1186/s13041-016-0277-4

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