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High angular resolution diffusion-weighted imaging in mild traumatic brain injury

We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography. DW-MRI wa...

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Autores principales: Mohammadian, Mehrbod, Roine, Timo, Hirvonen, Jussi, Kurki, Timo, Ala-Seppälä, Henna, Frantzén, Janek, Katila, Ari, Kyllönen, Anna, Maanpää, Henna-Riikka, Posti, Jussi, Takala, Riikka, Tallus, Jussi, Tenovuo, Olli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144744/
https://www.ncbi.nlm.nih.gov/pubmed/27981032
http://dx.doi.org/10.1016/j.nicl.2016.11.016
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author Mohammadian, Mehrbod
Roine, Timo
Hirvonen, Jussi
Kurki, Timo
Ala-Seppälä, Henna
Frantzén, Janek
Katila, Ari
Kyllönen, Anna
Maanpää, Henna-Riikka
Posti, Jussi
Takala, Riikka
Tallus, Jussi
Tenovuo, Olli
author_facet Mohammadian, Mehrbod
Roine, Timo
Hirvonen, Jussi
Kurki, Timo
Ala-Seppälä, Henna
Frantzén, Janek
Katila, Ari
Kyllönen, Anna
Maanpää, Henna-Riikka
Posti, Jussi
Takala, Riikka
Tallus, Jussi
Tenovuo, Olli
author_sort Mohammadian, Mehrbod
collection PubMed
description We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography. DW-MRI was performed on 102 patients with mTBI within two months post-injury and 30 control subjects. A robust global approach considering only the voxels with a single-fiber configuration was used in addition to global analysis of the tract skeleton and probabilistic whole-brain tractography. In addition, we assessed whether the microstructural parameters correlated with age, time from injury, patient's outcome and white matter MRI hyperintensities. We found that whole-brain global approach restricted to single-fiber voxels showed significantly decreased fractional anisotropy (FA) (p = 0.002) and increased radial diffusivity (p = 0.011) in patients with mTBI compared with controls. The results restricted to single-fiber voxels were more significant and reproducible than those with the complete tract skeleton or the whole-brain tractography. FA correlated with patient outcomes, white matter hyperintensities and age. No correlation was observed between FA and time of scan post-injury. In conclusion, the global approach could be a promising imaging biomarker to detect white matter abnormalities following traumatic brain injury.
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spelling pubmed-51447442016-12-15 High angular resolution diffusion-weighted imaging in mild traumatic brain injury Mohammadian, Mehrbod Roine, Timo Hirvonen, Jussi Kurki, Timo Ala-Seppälä, Henna Frantzén, Janek Katila, Ari Kyllönen, Anna Maanpää, Henna-Riikka Posti, Jussi Takala, Riikka Tallus, Jussi Tenovuo, Olli Neuroimage Clin Regular Article We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography. DW-MRI was performed on 102 patients with mTBI within two months post-injury and 30 control subjects. A robust global approach considering only the voxels with a single-fiber configuration was used in addition to global analysis of the tract skeleton and probabilistic whole-brain tractography. In addition, we assessed whether the microstructural parameters correlated with age, time from injury, patient's outcome and white matter MRI hyperintensities. We found that whole-brain global approach restricted to single-fiber voxels showed significantly decreased fractional anisotropy (FA) (p = 0.002) and increased radial diffusivity (p = 0.011) in patients with mTBI compared with controls. The results restricted to single-fiber voxels were more significant and reproducible than those with the complete tract skeleton or the whole-brain tractography. FA correlated with patient outcomes, white matter hyperintensities and age. No correlation was observed between FA and time of scan post-injury. In conclusion, the global approach could be a promising imaging biomarker to detect white matter abnormalities following traumatic brain injury. Elsevier 2016-11-17 /pmc/articles/PMC5144744/ /pubmed/27981032 http://dx.doi.org/10.1016/j.nicl.2016.11.016 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Mohammadian, Mehrbod
Roine, Timo
Hirvonen, Jussi
Kurki, Timo
Ala-Seppälä, Henna
Frantzén, Janek
Katila, Ari
Kyllönen, Anna
Maanpää, Henna-Riikka
Posti, Jussi
Takala, Riikka
Tallus, Jussi
Tenovuo, Olli
High angular resolution diffusion-weighted imaging in mild traumatic brain injury
title High angular resolution diffusion-weighted imaging in mild traumatic brain injury
title_full High angular resolution diffusion-weighted imaging in mild traumatic brain injury
title_fullStr High angular resolution diffusion-weighted imaging in mild traumatic brain injury
title_full_unstemmed High angular resolution diffusion-weighted imaging in mild traumatic brain injury
title_short High angular resolution diffusion-weighted imaging in mild traumatic brain injury
title_sort high angular resolution diffusion-weighted imaging in mild traumatic brain injury
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144744/
https://www.ncbi.nlm.nih.gov/pubmed/27981032
http://dx.doi.org/10.1016/j.nicl.2016.11.016
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